2020
Microsatellite instability and KRAS mutation in stage 4 CRC: Prevalence, geographic discrepancies and outcomes from the National Cancer Database.
Uhlig J, Cecchini M, Stein S, Lacy J, Kim K. Microsatellite instability and KRAS mutation in stage 4 CRC: Prevalence, geographic discrepancies and outcomes from the National Cancer Database. Journal Of Clinical Oncology 2020, 38: e16052-e16052. DOI: 10.1200/jco.2020.38.15_suppl.e16052.Peer-Reviewed Original ResearchNational Cancer DatabaseOverall survivalKRAS statusKRAS mutationsMicrosatellite instabilityMicrosatellite statusCancer DatabaseCRC siteStage IV colorectal adenocarcinomaStage IV CRC patientsUnited States National Cancer DatabaseCox proportional hazards modelStage IV CRCKRAS mutation rateRight-sided CRCProportional hazards modelDistinct prognostic profilesStatistical interaction testsKRAS wildtypePatient demographicsCRC patientsMetastatic burdenCRC treatmentMultivariable analysisPrognostic profilePD-1 targeted immunotherapy for advanced hepatocellular cancer: Current utilization and outcomes in the United States.
Uhlig J, Stein S, Kim K. PD-1 targeted immunotherapy for advanced hepatocellular cancer: Current utilization and outcomes in the United States. Journal Of Clinical Oncology 2020, 38: e16647-e16647. DOI: 10.1200/jco.2020.38.15_suppl.e16647.Peer-Reviewed Original ResearchAdvanced hepatocellular carcinomaHepatocellular carcinomaOverall survivalPD-1Multivariable analysisLiver disease risk factorsCox proportional hazards modelBilirubin resultsAdvanced hepatocellular cancerClinical performance statusLiver disease complicationsOverall survival benefitDisease risk factorsDeath protein 1Longer overall survivalOncological treatment strategiesProportional hazards modelDe-identified databaseSystemic sorafenibAdult patientsHCC resectionPatient demographicsPerformance statusSurvival benefitIndependent prognosticatorAssociation of real-world agreement between HER2 expression and ERBB2 amplification with trastuzumab therapy benefit in advanced gastric/esophageal (adv GE) cancer patients (pts).
Stein S, Snider J, McCusker M, Miksad R, Alexander B, Castellanos E, Backenroth D, Schrock A, Madison R, Carson K, Ali S. Association of real-world agreement between HER2 expression and ERBB2 amplification with trastuzumab therapy benefit in advanced gastric/esophageal (adv GE) cancer patients (pts). Journal Of Clinical Oncology 2020, 38: 310-310. DOI: 10.1200/jco.2020.38.4_suppl.310.Peer-Reviewed Original ResearchComprehensive genomic profilingAdjusted hazard ratioGE cancersOverall survivalERBB2 copy numberERBB2 amplificationClinical outcomesUnadjusted Kaplan-Meier analysisCox proportional hazards modelMedian overall survivalKaplan-Meier analysisEsophageal cancer patientsProportional hazards modelLonger OSHazard ratioMedian ageCancer patientsHER2 expressionHER2 statusTherapy benefitHazards modelHER2Median TTDClinical databaseDiscordant testsNeuroendocrine and carcinoid tumors of the gastrointestinal tract: Epidemiology and outcomes from the National Cancer Database.
Uhlig J, Nie J, Stein S, Cecchini M, Lacy J, Kim H. Neuroendocrine and carcinoid tumors of the gastrointestinal tract: Epidemiology and outcomes from the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 609-609. DOI: 10.1200/jco.2020.38.4_suppl.609.Peer-Reviewed Original ResearchNational Cancer DatabaseNeuroendocrine tumorsOverall survivalSmall intestineSurgical resectionYounger patientsCancer DatabaseGastrointestinal tractImproved overall survivalPrimary disease siteLonger overall survivalPrimary cancer siteProportional hazards modelAfrican AmericansLower stageConcurrent chemotherapyMultivariable adjustmentAdult patientsMost metastasesPatient agePatient demographicsIndependent prognosticatorCarcinoid tumorsHepatic metastasesTumor size
2019
KRAS mutation and microsatellite instability in colorectal cancer: Screening pattern and mutational landscape across the US.
Uhlig J, Stein S, Lacy J, Kim H. KRAS mutation and microsatellite instability in colorectal cancer: Screening pattern and mutational landscape across the US. Journal Of Clinical Oncology 2019, 37: e15138-e15138. DOI: 10.1200/jco.2019.37.15_suppl.e15138.Peer-Reviewed Original ResearchOverall survivalColorectal cancerKRAS mutationsMicrosatellite instabilityNon-metastatic colorectal cancerPropensity scoreCox proportional hazards modelMetastatic colorectal cancerNational Cancer DatabasePatients' overall survivalProportional hazards modelMutational screeningDistinct mutational patternsPatient ageYounger patientsMutational prevalenceCancer DatabaseCancer factorsCRC siteFemale African AmericansHazards modelAcademic centersEast South CentralPatientsFemale CaucasiansImpact of direct-acting antivirals and 12-week sustained viral response on clinical outcomes in patients with hepatitis C and hepatocellular carcinoma.
Kamp W, Sellers C, Stein S, Lim J, Kim H. Impact of direct-acting antivirals and 12-week sustained viral response on clinical outcomes in patients with hepatitis C and hepatocellular carcinoma. Journal Of Clinical Oncology 2019, 37: 397-397. DOI: 10.1200/jco.2019.37.4_suppl.397.Peer-Reviewed Original ResearchHepatitis C viral infectionDAA therapyOverall survivalHepatocellular carcinomaMultivariable analysisViral responseHCC patientsTumor locationTreatment allocationHigher OSMultivariable Cox proportional hazards modelsUrban tertiary care hospitalCox proportional hazards modelHCV-negative patientsChild-Pugh scoreMedian overall survivalSustained viral responseTertiary care hospitalC viral infectionKaplan-Meier curvesProportional hazards modelDAA patientsHCV patientsHepatitis CMELD score