2023
Effector response to necroptotic cell death: an ensemble of immune and stromal cells.
Hughes L, Altun O, Nevin J, Wang M, Kluger Y, Pelorosso F, Leighton J, Rothlin C, Ghosh S. Effector response to necroptotic cell death: an ensemble of immune and stromal cells. The Journal Of Immunology 2023, 210: 72.39-72.39. DOI: 10.4049/jimmunol.210.supp.72.39.Peer-Reviewed Original ResearchApoptotic cell deathCell deathGene expression programsEffector responsesNecroptotic cell deathSingle-cell levelMyofibroblast transitionExpression programsStromal cellsTissue renewalTranscriptomic changesCellular corpsesInflammatory bowel diseaseExcessive inflammatory responseInfluence of TGFChemo-genetic approachNon-resolving inflammationMolecular pathwaysResolution of inflammationEssential roleMajor stromal cellsBowel diseaseInflammatory responseInjury modelHelminth infections
2019
Induction of sterile type 2 inflammation
de Kouchkovsky DA, Ghosh S, Rothlin CV. Induction of sterile type 2 inflammation. Nature Materials 2019, 18: 193-194. PMID: 30783225, PMCID: PMC7081377, DOI: 10.1038/s41563-019-0300-0.Commentaries, Editorials and LettersConceptsType 2 inflammatory responsesType 2 inflammationInflammatory responseProsthetic implantsInflammation
2014
Tyro3, Axl, and Mertk Receptor Signaling in Inflammatory Bowel Disease and Colitis-associated Cancer
Rothlin CV, Leighton JA, Ghosh S. Tyro3, Axl, and Mertk Receptor Signaling in Inflammatory Bowel Disease and Colitis-associated Cancer. Inflammatory Bowel Diseases 2014, 20: 1472-1480. PMID: 24846720, PMCID: PMC4343000, DOI: 10.1097/mib.0000000000000050.BooksConceptsInflammatory bowel diseaseBowel diseaseImmune responseT-cell-dependent adaptive immune responsesApoptotic cellsReceptor tyrosine kinasesProinflammatory cytokine productionSuppression of inflammationAdaptive immune responsesInnate immune responseTAM receptor tyrosine kinasesPotent therapeutic opportunityDisease remissionTyrosine kinaseIntestinal inflammationCytokine productionInflammatory responseLigand Gas6Potent negative regulatorTherapeutic opportunitiesGenetic ablationInflammationProtein SReceptor signalingSuccessful management
2007
TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response
Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response. Cell 2007, 131: 1124-1136. PMID: 18083102, DOI: 10.1016/j.cell.2007.10.034.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxl Receptor Tyrosine KinaseC-Mer Tyrosine KinaseDendritic CellsGene Expression RegulationImmunity, InnateInflammationMiceMice, KnockoutOncogene ProteinsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptor, Interferon alpha-betaSignal TransductionSTAT1 Transcription FactorSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsToll-Like ReceptorsUbiquitinationConceptsToll-like receptorsDendritic cellsImmune responseChronic inflammatory milieuInnate immune responseTAM receptor tyrosine kinasesRapid inflammatory responseType I interferon receptorCytokine-dependent activationTAM inhibitionTLR inductionInflammatory milieuInflammatory responseProinflammatory pathwaysTAM receptorsTLR signalingPleiotropic inhibitorInflammationReceptor tyrosine kinasesTranscription factor STAT1Interferon receptorEssential stimulatorReceptorsTyrosine kinaseTAM system