2014
Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death
Scuderi S, D’Amico A, Castorina A, Federico C, Marrazzo G, Drago F, Bucolo C, D’Agata V. Davunetide (NAP) Protects the Retina Against Early Diabetic Injury by Reducing Apoptotic Death. Journal Of Molecular Neuroscience 2014, 54: 395-404. PMID: 24488575, DOI: 10.1007/s12031-014-0244-4.Peer-Reviewed Original ResearchConceptsNAP treatmentRetinas of STZSingle intraocular injectionCaspase-3 expression levelsRetinal degenerative diseasesMAPK/ERK pathwayPhosphatidylinositol-3-kinase/Akt pathwayMitogen-activated protein kinase/extracellular signal-regulated protein kinaseDiabetes inductionDiabetic injuryDiabetic retinaSTZ injectionNeuroprotective effectsDiabetic modelIntraocular injectionPotent neuroprotectionDiabetic retinopathyVivo streptozotocinRetinal expressionProtein kinase/extracellular signal-regulated protein kinaseAmino acid peptideKinase/Akt pathwayP-AktP-ERKApoptosis markers
2012
Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells
Castorina A, Giunta S, Scuderi S, D’Agata V. Involvement of PACAP/ADNP Signaling in the Resistance to Cell Death in Malignant Peripheral Nerve Sheath Tumor (MPNST) Cells. Journal Of Molecular Neuroscience 2012, 48: 674-683. PMID: 22454142, DOI: 10.1007/s12031-012-9755-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCulture Media, Serum-FreeDNA ReplicationDNA, NeoplasmDose-Response Relationship, DrugGene Expression Regulation, NeoplasticHydrogen PeroxideNeoplasm ProteinsNerve Sheath NeoplasmsNerve Tissue ProteinsPituitary Adenylate Cyclase-Activating PolypeptideRatsReal-Time Polymerase Chain ReactionReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IReceptors, Vasoactive Intestinal Peptide, Type IISignal TransductionTumor Cells, CulturedConceptsMalignant peripheral nerve sheath tumorActivity-dependent neuroprotective proteinMPNST cellsNormal serumSS cellsADNP expressionMalignant peripheral nerve sheath tumor cellsPeripheral nerve sheath tumorsNerve sheath tumorsCyclase-activating polypeptideVPAC receptor antagonistSheath tumorsReceptor antagonistNeuroprotective proteinTumor cellsSerum starvationMetabolic stressCaspase-3DeathCell viabilityDNA fragmentationInvolvementCell resistanceCellsSurvival response
2011
Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate
Giunta S, Castorina A, Scuderi S, Patti C, D’Agata V. Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate. Toxicology In Vitro 2011, 26: 280-287. PMID: 22210268, DOI: 10.1016/j.tiv.2011.12.012.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorPhosphorylated proteinsGrowth factor receptorFactor receptorBcl-2Suppression of apoptosisAirway epithelial cellsEpithelial cellsReduced EGFRBax protein expressionApoptosis initiationEpithelial cell lineBEAS-2B cellsCell deathDNA fragmentationDNA damageAirway epithelial cell lineHuman airway epithelial cellsExpression levelsProteinApoptosisProtein expressionCell linesInitiation of carcinogenesisPotential involvement