2015
Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications
Marzagalli R, Scuderi S, Drago F, Waschek J, Castorina A. Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications. International Journal Of Endocrinology 2015, 2015: 160928. PMID: 26074958, PMCID: PMC4446501, DOI: 10.1155/2015/160928.Peer-Reviewed Original ResearchMajor complicationsNeuropeptide pituitary adenylate cyclaseMajor diabetes complicationsMajor diabetic complicationsNew potential therapeutic targetsCause of morbidityCause of diabetesPituitary adenylate cyclasePotential therapeutic targetRole of PACAPPancreatic islet dysfunctionLongstanding diabetesDiabetes complicationsRange of pathologiesDiabetic complicationsHyperglycemic stateMillions of individualsIslet dysfunctionPeptide-based therapiesComplicationsTherapeutic targetDiabetesAdenylate cyclaseSecondary damageLife expectancy
2012
Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction
Scuderi S, D’Amico A, Castorina A, Imbesi R, Carnazza M, D’Agata V. Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction. Peptides 2012, 39: 119-124. PMID: 23220033, DOI: 10.1016/j.peptides.2012.11.015.Peer-Reviewed Original ResearchMeSH KeywordsBlood-Retinal BarrierCapillary PermeabilityCell LineClaudin-1DextransDiabetes ComplicationsElectric ImpedanceFluorescein-5-isothiocyanateGene ExpressionGlucoseHumansInterleukin-1betaMacular EdemaOccludinPituitary Adenylate Cyclase-Activating PolypeptideRetinal Pigment EpitheliumTight JunctionsVasoactive Intestinal PeptideZonula Occludens-1 ProteinConceptsDiabetic macular edemaBlood-retinal barrierTransepithelial electrical resistanceBRB functionBlood-retinal barrier dysfunctionOuter blood-retinal barrierEffects of PACAPHuman retinal pigment epithelial cellsFITC-dextran diffusionRetinal pigment epithelial cellsZO-1 expressionTight junctionsPigment epithelial cellsMacular edemaMajor complicationsInflammatory aspectsRetinal barrierRetinal injuryBarrier dysfunctionIL-1βDiabetic retinopathyDiabetic milieuTJ-related proteinsOccludin expressionNormal glucose