Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth
Buhimschi C, Dulay A, Abdel‐Razeq S, Zhao G, Lee S, Hodgson E, Bhandari V, Buhimschi I. Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth. BJOG An International Journal Of Obstetrics & Gynaecology 2008, 116: 257-267. PMID: 18947340, PMCID: PMC3791329, DOI: 10.1111/j.1471-0528.2008.01925.x.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisCord blood IL-6 levelsBlood IL-6 levelsIntra-amniotic inflammationIL-6 levelsIL-6 ratioFetal inflammatory responseInflammatory statusCord bloodInflammatory responseProteomic biomarkersGestational ageAF IL-6 levelsCord blood IL-6Tertiary referral university hospitalAmniotic fluid biomarkersProspective observational cohortBlood IL-6Neonates of womenInterleukin-6 levelsReferral university hospitalIntra-amniotic infectionEarlier gestational ageDifferential inflammatory responsePositive blood culturesFetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation
Buhimschi C, Abdel-Razeq S, Cackovic M, Pettker C, Dulay A, Bahtiyar M, Zambrano E, Martin R, Norwitz E, Bhandari V, Buhimschi I. Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation. American Journal Of Perinatology 2008, 25: 359-372. PMID: 18512201, PMCID: PMC2724874, DOI: 10.1055/s-2008-1078761.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisIntra-amniotic inflammationFetal heart rate monitoring patternsHistological chorioamnionitisPreterm birthPredictive valueAcute histological chorioamnionitisFetuses of womenHuman Development criteriaUseful clinical indicatorNegative predictive valuePositive predictive valueMonitoring patternsNeonatal sepsisPremature neonatesGestational ageLaboratory criteriaAntibiotic treatmentClinical indicatorsChild healthSensitive predictorInflammationAdmissionNeonatesInitial evaluation