2013
836: Limiting exposure of a select group of fetuses to intra-amniotic infection (IAI) may improve short-term neonatal outcome in pregnancies complicated by PPROM
Archabald K, Buhimschi I, Bahtiyar M, Dulay A, Abdel-Razeq S, Pettker C, Lipkind H, Hardy J, McCarthy M, Zhao G, Bhandari V, Buhimschi C. 836: Limiting exposure of a select group of fetuses to intra-amniotic infection (IAI) may improve short-term neonatal outcome in pregnancies complicated by PPROM. American Journal Of Obstetrics And Gynecology 2013, 208: s349-s350. DOI: 10.1016/j.ajog.2012.10.174.Peer-Reviewed Original ResearchIntra-amniotic infectionShort-term neonatal outcomesNeonatal outcomesSelect groupPPROMPregnancyFetusesInfection
2011
Modulation of Amniotic Fluid Activin‐A and Inhibin‐A in Women With Preterm Premature Rupture of the Membranes and Infection‐Induced Preterm Birth
Rosenberg VA, Buhimschi IA, Dulay AT, Abdel‐Razeq S, Oliver EA, Duzyj CM, Lipkind H, Pettker CM, Buhimschi CS. Modulation of Amniotic Fluid Activin‐A and Inhibin‐A in Women With Preterm Premature Rupture of the Membranes and Infection‐Induced Preterm Birth. American Journal Of Reproductive Immunology 2011, 67: 122-131. PMID: 21992678, PMCID: PMC3253234, DOI: 10.1111/j.1600-0897.2011.01074.x.Peer-Reviewed Original ResearchConceptsPreterm premature rupturePreterm birthPremature ruptureVillous explantsRecombinant activinInflammation-induced preterm birthRelease of activinIntra-amniotic infectionPlacental villous explantsIL-8 releasePreterm laborInflammatory processInflammatory reactionGram-negative lipopolysaccharideInhibinFetal membranesHuman AFImportant modulatorAF samplesInfectionActivinLipopolysaccharidePPROMAmniochorionIntact membranes625: Systematic evaluation of prototype acute phase reactants [Interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT)] as non-invasive biomarkers of intra-amniotic infection (IAI)
Dulay A, Buhimschi I, Zhao G, Ali U, Abdel-Razeq S, Bahtiyar M, Thung S, Han C, Campbell K, Paidas M, Buhimschi C. 625: Systematic evaluation of prototype acute phase reactants [Interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT)] as non-invasive biomarkers of intra-amniotic infection (IAI). American Journal Of Obstetrics And Gynecology 2011, 204: s248. DOI: 10.1016/j.ajog.2010.10.645.Peer-Reviewed Original Research
2008
Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth
Buhimschi C, Dulay A, Abdel‐Razeq S, Zhao G, Lee S, Hodgson E, Bhandari V, Buhimschi I. Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth. BJOG An International Journal Of Obstetrics & Gynaecology 2008, 116: 257-267. PMID: 18947340, PMCID: PMC3791329, DOI: 10.1111/j.1471-0528.2008.01925.x.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisCord blood IL-6 levelsBlood IL-6 levelsIntra-amniotic inflammationIL-6 levelsIL-6 ratioFetal inflammatory responseInflammatory statusCord bloodInflammatory responseProteomic biomarkersGestational ageAF IL-6 levelsCord blood IL-6Tertiary referral university hospitalAmniotic fluid biomarkersProspective observational cohortBlood IL-6Neonates of womenInterleukin-6 levelsReferral university hospitalIntra-amniotic infectionEarlier gestational ageDifferential inflammatory responsePositive blood cultures475: The interleukin-6 (IL-6) trans-signaling system: Evidence for presence and activation in pregnancies complicated by intra-amniotic infection
Lee S, Buhimschi I, Zhao G, Dulay A, Wehrum M, Abdel-Razeq S, Baumbusch M, Buhimschi C. 475: The interleukin-6 (IL-6) trans-signaling system: Evidence for presence and activation in pregnancies complicated by intra-amniotic infection. American Journal Of Obstetrics And Gynecology 2008, 199: s141. DOI: 10.1016/j.ajog.2008.09.504.Peer-Reviewed Original Research
2007
194: A role for the amniotic fluid inhibin (INH) — activin (ACT) system in preterm premature rupture of the membranes and intra-amniotic infection
Rosenberg V, Buhimschi C, Dulay A, Oliver E, Jing S, Pettker C, Abdel-Razeq S, Cackovic M, Luo G, Buhimschi I. 194: A role for the amniotic fluid inhibin (INH) — activin (ACT) system in preterm premature rupture of the membranes and intra-amniotic infection. American Journal Of Obstetrics And Gynecology 2007, 197: s65. DOI: 10.1016/j.ajog.2007.10.207.Peer-Reviewed Original Research
2006
Lactate dehydrogenase (LDH) isoform activity in the vaginal “pool” - a marker of intra-amniotic infection in women with preterm premature rupture of membranes
Magloire L, Buhimschi C, Pettker C, Abdel-Razeq S, Rosenberg V, Cackovic M, Bahtiyar M, Buhimschi I. Lactate dehydrogenase (LDH) isoform activity in the vaginal “pool” - a marker of intra-amniotic infection in women with preterm premature rupture of membranes. American Journal Of Obstetrics And Gynecology 2006, 195: s64. DOI: 10.1016/j.ajog.2006.10.199.Peer-Reviewed Original Research