2020
Minor Physical Anomalies in Bipolar Disorder
İnce B, Altinoz M, Ayran A, Cansız A, Altinbaş K, Guloksuz S, Kurt E. Minor Physical Anomalies in Bipolar Disorder. Comprehensive Psychiatry 2020, 103: 152206. PMID: 33099105, DOI: 10.1016/j.comppsych.2020.152206.Peer-Reviewed Original ResearchConceptsBipolar disorderMinor physical anomaliesBD patientsHealthy subjectsHigh arched palatePhysical anomaliesAuricular anomaliesPsychiatric disordersCleft lipPathogenesis pathwaysPatientsMinor anomaliesDeletion syndromeDisordersSecond pharyngeal archesDorsal endPalateSchizophreniaRegression modelsAuriclePharyngeal archesFirst pharyngeal archArchNew endophenotypesSubjects
2019
Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
van Os J, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study. Psychological Medicine 2019, 50: 1884-1897. PMID: 31414981, DOI: 10.1017/s003329171900196x.Peer-Reviewed Original ResearchConceptsPsychotic disordersPolygenic riskSchizophrenia polygenic riskGene-environment interactionsGenetic riskRelatives of patientsFirst-degree relativesPsychosis phenotypeAverage genetic riskIntermediate phenotypesHealthy siblingsCognitive intermediate phenotypesControl groupAnalysis of associationAverage riskPatients