2022
Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?
Fusar-Poli L, Rutten B, van Os J, Aguglia E, Guloksuz S. Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype? International Review Of Psychiatry 2022, 34: 663-675. PMID: 36786114, DOI: 10.1080/09540261.2022.2101352.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresTreatment responseRisk scoreMental disordersDetailed clinical characterizationPresent narrative reviewPotential clinical utilityMajor mental disordersIndividual genetic predispositionRisk stratificationPrognostic evaluationClinical characterizationWide association study datasetsClinical utilityGeneral populationGenetic predispositionNarrative reviewSingle nucleotide polymorphisms
2021
Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness
Luykx J, Loef D, Lin B, van Diermen L, Nuninga J, van Exel E, Oudega M, Rhebergen D, Schouws S, van Eijndhoven P, Verwijk E, Schrijvers D, Birkenhager T, Ryan K, Arts B, van Bronswijk S, Kenis G, Schurgers G, Baune B, Arns M, van Dellen E, Somers M, Sommer I, Boks M, Gülöksüz S, McLoughlin D, Dols A, Rutten B. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness. Biological Psychiatry 2021, 91: 531-539. PMID: 34955169, DOI: 10.1016/j.biopsych.2021.10.013.Peer-Reviewed Original ResearchConceptsMajor depressive episodeHamilton Depression Rating Scale scoresDepression Rating Scale scoresRating Scale scoresPolygenic risk scoresPRS-SCZECT outcomeElectroconvulsive therapyScale scoreSevere major depressive episodeUnipolar major depressive episodeMajor depressive disorderSecondary outcomesAntidepressant responseECT treatmentDepressive episodeSubgroup analysisECT effectivenessPsychotic featuresDepressive disorderTreatment responseMAIN OUTCOMEEffective treatmentRisk scoreTherapy effectivenessRisk profiles for mental disorders
Gülöksüz S. Risk profiles for mental disorders. European Psychiatry 2021, 64: s71-s71. PMCID: PMC9471330, DOI: 10.1192/j.eurpsy.2021.220.Peer-Reviewed Original ResearchPsychiatric diagnosisSame psychiatric diagnosisDifferent psychiatric diagnosesSame treatment protocolClinical staging modelRisk profilingDiagnosis-specific treatmentsSame treatment planTreatment protocolTreatment responseMedical conditionsClinical practiceDiagnostic classification systemsTreatment planMental disordersStaging modelRisk profileDiscrete diagnostic categoriesPatientsDiagnostic categoriesClinical predictionDiagnosisEarly psychopathologyTraditional diagnostic boundariesPrognostication
2018
Evaluation of the Association between Lithium Treatment and GSK3β Polymorphism in Bipolar Disorder Patients.
Altınbaş K, Yeşilbaş D, İnce B, Cansız A, Sılan F, Özdemir Ö, Gülöksüz S. Evaluation of the Association between Lithium Treatment and GSK3β Polymorphism in Bipolar Disorder Patients. Turkish Journal Of Psychiatry 2018, 29: 73-78. PMID: 30215834, DOI: 10.5080/u20582.Peer-Reviewed Original ResearchConceptsMean ageLithium treatmentTreatment responseGSK-3βBipolar disorder type IBipolar disorder patientsLack of evidenceClinical predictorsHospital recordsTreatment adherenceTreatment optionsDisease onsetFirst episodeReal-time PCRIndividualized treatmentPharmacogenomic findingsBlood samplesDisorder patientsSide effectsAG genotypeClinical practiceScale scoreBipolar disorderPatientsSample cohort
2012
Plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms
Cetin T, Guloksuz S, Cetin E, Gazioglu S, Deniz G, Oral E, van Os J. Plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms. BMC Psychiatry 2012, 12: 158. PMID: 23013558, PMCID: PMC3532147, DOI: 10.1186/1471-244x-12-158.Peer-Reviewed Original ResearchEvidence for an association between tumor necrosis factor-alpha levels and lithium response
Guloksuz S, Altinbas K, Cetin E, Kenis G, Gazioglu S, Deniz G, Oral E, van Os J. Evidence for an association between tumor necrosis factor-alpha levels and lithium response. Journal Of Affective Disorders 2012, 143: 148-152. PMID: 22749155, DOI: 10.1016/j.jad.2012.04.044.Peer-Reviewed Original ResearchConceptsTNF-α levelsBipolar patientsLithium responsePartial responseTumor necrosis factor-alpha levelsBipolar disorderTreatment-resistant bipolar patientsNecrosis factor-alpha levelsRole of inflammationPotential pathophysiological mechanismsAdditional inflammatory markersAssessment of responseGood responseEnzyme-linked immunosorbentEuthymic bipolar patientsImmune imbalanceImmune alterationsInflammatory markersImmune changesPathophysiological mechanismsPotential confoundersLithium therapyNatural coursePoor responseTreatment response