2023
The association between polygenic risk scores for mental disorders and social cognition: A scoping review
Fusar-Poli L, Rodolico A, Martinez M, Fichera C, Lin B, Basadonne I, Concerto C, Aguglia E, Guloksuz S, Signorelli M. The association between polygenic risk scores for mental disorders and social cognition: A scoping review. Journal Of Psychiatric Research 2023, 164: 389-401. PMID: 37418886, DOI: 10.1016/j.jpsychires.2023.06.029.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial cognitionMental disordersAttention deficit hyperactivity disorderReal-world functioningSC deficitsEmotion recognitionHyperactivity disorderSpectrum disorderPresent impairmentsPolygenic risk scoresCognitionFuture researchMolecular genetic riskSignificant difficultiesSpecific disordersDisordersUnaffected relativesGenetic riskRisk scorePeopleUnderstanding of mechanismsFunctioningEnvironmental risk factorsScores
2022
Longitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study
Erzin G, Pries L, Dimitrakopoulos S, Ralli I, Xenaki L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Rizos E, Kollias K, Os J, Guloksuz S, Stefanis N. Longitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study. European Psychiatry 2022, 65: s760-s760. PMCID: PMC9567635, DOI: 10.1192/j.eurpsy.2022.1963.Peer-Reviewed Original ResearchPANSS total scoreFirst-episode psychosisClinical featuresES-SCZTotal scoreIllness coursePsychosis developmentLongitudinal associationsEnvironmental exposuresTime interactionNegative Syndrome ScaleExposome scoreEpisode psychosisSyndrome ScaleSymptom severitySchizophreniaEnvironmental predispositionMultilevel regression analysisScoresRegression analysisFollowPrevious reportsBaselineAssociationCurrent study
2020
Phenome-wide and genome-wide analyses of quality of life in schizophrenia
Pazoki R, Lin B, van Eijk K, Schijven D, de Zwarte S, Alizadeh B, van Amelsvoort T, Bartels-Velthuis A, van Beveren N, Bruggeman R, Cahn W, de Haan L, Delespaul P, Luykx J, Myin-Germeys I, Kahn R, Schirmbeck F, Simons C, van Os J, van Winkel R, Guloksuz S, Luykx J. Phenome-wide and genome-wide analyses of quality of life in schizophrenia. BJPsych Open 2020, 7: e13. PMID: 33295273, PMCID: PMC7791571, DOI: 10.1192/bjo.2020.140.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scoreClinical phenotypeNon-genetic contributing factorsMajor depressive disorderQuality of lifeDepressive disorderHealthy controlsVulnerable patientsStudy populationHypothesis-generating approachPatientsPsychotic disordersQoLSmall studyClinical interventionsSchizophreniaGenotypic determinantsScoresContributing factorDisordersPhenotypeAssociationPredictive Performance of Exposome Score for Schizophrenia in the General Population
Pries L, Erzin G, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Guloksuz S. Predictive Performance of Exposome Score for Schizophrenia in the General Population. Schizophrenia Bulletin 2020, 47: 277-283. PMID: 33215211, PMCID: PMC7965069, DOI: 10.1093/schbul/sbaa170.Peer-Reviewed Original ResearchConceptsES-SCZOptimal cut pointGeneral populationPopulation cohortGeneral population cohortCut pointsExposome scoreSchizophrenia spectrum disordersMeta-analytical estimatesClinical outcomesRisk strataRisk stratificationMulticausal etiologyMedical outcomesPsychiatric diagnosisBipolar disorderSchizophrenia diagnosisExposure scoreSuicide planSum scoreGene-environment interaction studiesSchizophreniaRisk predictionCharacteristic curveScores
2019
Affective Temperament and Seasonality in Bipolar Disorder.
Altınbaş K, İnce B, Gülöksüz S. Affective Temperament and Seasonality in Bipolar Disorder. Psychiatria Danubina 2019, 31: 106-110. PMID: 30948697, DOI: 10.24869/psyd.2019.106.Peer-Reviewed Original ResearchConceptsBipolar disorderIllness courseSeasonal Pattern Assessment QuestionnaireAffective temperamentsAnxious temperament scoresAssessment QuestionnaireEuthymic patientsTemperament scoresAffective temperament scoresTotal scoreMood regulationVersion scalePatientsScoresFurther investigationDisordersCourse