2024
The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Drukker M, Todor T, Bongaarts J, Broggi E, Kelkar M, Wigglesworth T, Verhiel K, van Leeuwen K, Koster M, Derom C, Thiery E, De Hert M, Menne-Lothmann C, Decoster J, Collip D, van Winkel R, Jacobs N, Guloksuz S, Rutten B, van Os J. The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. BMC Psychiatry 2024, 24: 736. PMID: 39462331, PMCID: PMC11515186, DOI: 10.1186/s12888-024-06176-2.Peer-Reviewed Original ResearchConceptsAberrant salienceGeneral population twinsPsychotic experiencesGenetic vulnerabilityGeneral population samplePsychotic symptomsAssociated with psychotic experiencesUltra-high-risk patientsPositive symptom scalesSubclinical psychotic symptomsWhite noise taskEpisode psychosis patientsAssociated with psychosisPopulation samplePsychosis spectrumPsychosis patientsSymptom ScaleNoise taskSaliencePsychosisSevere endVulnerabilitySymptomsTaskAssociation
2023
The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service
Ferrara M, Guloksuz S, Hazan H, Li F, Tek C, Sykes L, Riley S, Keshavan M, Srihari V. The effect of duration of untreated psychosis (DUP) on the risk for hospitalization after admission to a first episode service. Schizophrenia Research 2023, 260: 198-204. PMID: 37688984, DOI: 10.1016/j.schres.2023.08.005.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesLength of stayUntreated psychosisPsychiatric hospitalizationFirst-episode servicesDuration of hospitalizationIncidence rate ratiosNon-affective psychosisNew Haven areaPoisson regression modelsPatient characteristicsHospitalization ratesRecent onsetMedical recordsHospitalizationEffect of durationNegative binomial regressionSpecialized treatmentPsychosisRate ratioBinomial regressionAdmissionDUPEnrollmentFirst yearAssociations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis
Ku B, Addington J, Bearden C, Cadenhead K, Cannon T, Compton M, Cornblatt B, Druss B, Gülöksüz S, Mathalon D, Perkins D, Tsuang M, Walker E, Woods S, Carrión R. Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 1437-1446. PMID: 37358832, PMCID: PMC10686327, DOI: 10.1093/schbul/sbad093.Peer-Reviewed Original ResearchConceptsClinical high riskHealthy comparisonsSocial functioningHigh riskPoor social functioningNorth American Prodrome Longitudinal StudyImportant risk factorRisk factorsPsychotic disordersEffective interventionsHealthy youthChildhoodLongitudinal studyAdulthoodPsychosisAssociationAdultsMaladaptationRiskSocial deficitsFurther researchFunctioningCommunity levelGender differences underlying the link between exposome and psychosis
Guloksuz S. Gender differences underlying the link between exposome and psychosis. European Psychiatry 2023, 66: s29-s30. PMCID: PMC10417599, DOI: 10.1192/j.eurpsy.2023.114.Peer-Reviewed Original ResearchGender-related differencesPsychosis riskChildhood adversitySubstance abuse comorbidityAssociation of psychosisObstetric complicationsDifferent symptom dimensionsSeason of birthHigh prevalencePsychotic disordersPubMed databaseSystematic reviewSubstance abusePsychosisSubstance useEnvironmental exposuresWomenUrban upbringingChildhood abuseSymptom dimensionsMenEarly ageRiskExposomeFuture studies
2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther supportReducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative
Ferrara M, Gallagher K, Yoviene Sykes LA, Markovich P, Li F, Pollard JM, Imetovski S, Cahill J, Guloksuz S, Srihari VH. Reducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative. Psychiatric Services 2022, 73: 1416-1419. PMID: 35652190, PMCID: PMC9715806, DOI: 10.1176/appi.ps.202100374.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesConfirmation of eligibilityEarly detection campaignsProportion of admissionsSpecialty care servicesQuality improvement interventionsQuality improvement initiativesLonger DUPMedian delayPoor outcomeUntreated psychosisTreatment accessPsychosis onsetPsychosis servicesCSC servicesCare servicesImprovement interventionsAdmissionImprovement initiativesDetection campaignsInterventionGreater vulnerabilityReferralPsychosisEstimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study
Pries L, Moore T, Visoki E, Sotelo I, Barzilay R, Guloksuz S. Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study. Biological Psychiatry Global Open Science 2022, 2: 283-291. PMID: 36325038, PMCID: PMC9616253, DOI: 10.1016/j.bpsgos.2022.05.005.Peer-Reviewed Original ResearchPregnancy/birth complicationsExposome factorsGeneral psychopathologyBirth complicationsCognitive Development StudyGeneral psychopathology factorAdolescent Brain Cognitive Development (ABCD) studyClinical symptomsAdjusted modelMultiple comparison correctionExposome approachLinear regression analysisMental disordersNeurodevelopmental psychopathologyChildhood adversityPsychosisEnvironmental exposuresABCD studyNongenetic factorsComplicationsRegression analysisPsychopathology factorNeighborhood environmentPsychopathologyExposomeEarly intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis
Shah J, Jones N, van Os J, McGorry P, Gülöksüz S. Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis. The Lancet Psychiatry 2022, 9: 413-422. PMID: 35430004, DOI: 10.1016/s2215-0366(21)00467-3.Peer-Reviewed Original ResearchConceptsRisk mental stateBroader mental health systemNon-psychotic disordersPerson-centred careMental health systemYouth mental healthClinical stagingEarly intervention service systemFirst episodeRelevance of outcomesEarly psychosisCenters of expertiseFrequent developmentDifferential riskClinical researchHealth systemPsychosisSpecific interventionsMental healthSyndromeMental statesDisordersTraditional diagnosisOutcomesClinicGender differences in the association between environment and psychosis
Pence AY, Pries LK, Ferrara M, Rutten BPF, van Os J, Guloksuz S. Gender differences in the association between environment and psychosis. Schizophrenia Research 2022, 243: 120-137. PMID: 35287098, DOI: 10.1016/j.schres.2022.02.039.Peer-Reviewed Original ResearchConceptsGender-related differencesChildhood adversityPsychosis riskSubstance useSubstance abuse comorbidityEnvironmental exposuresOnset of illnessAssociation of psychosisObstetric complicationsDifferent symptom dimensionsSeason of birthPsychosis spectrum disordersHigh prevalencePsychotic disordersPubMed databaseSystematic reviewPsychosisWomenChildhood abuseSymptom dimensionsMenEarly ageAssociationPsychosis expressionFurther investigationCorrigendum to: Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial
Srihari V, Ferrara M, Li F, Kline E, Gülöksüz S, Pollard J, Cahill J, Mathis W, Sykes L, Walsh B, McDermott G, Seidman L, Gueorguieva R, Woods S, Tek C, Keshavan M. Corrigendum to: Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial. Schizophrenia Bulletin Open 2022, 3: sgac020. PMID: 39144776, PMCID: PMC11206056, DOI: 10.1093/schizbullopen/sgac020.Peer-Reviewed Original Research
2021
P.0157 Association between exposome score for schizophrenia and functioning in first-episode psychosis: results from the athens first-episode psychosis research study
Erzin G, Dimitrakopoulos S, Ralli I, Pries L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Kollias K, Os J, Guloksuz S, Stefanis N. P.0157 Association between exposome score for schizophrenia and functioning in first-episode psychosis: results from the athens first-episode psychosis research study. European Neuropsychopharmacology 2021, 53: s114-s115. DOI: 10.1016/j.euroneuro.2021.10.153.Peer-Reviewed Original ResearchLongitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis
Oomen P, Begemann M, Brand B, de Haan L, Veling W, Koops S, van Os J, Smit F, Bakker P, van Beveren N, Boonstra N, Gülöksüz S, Kikkert M, Lokkerbol J, Marcelis M, Rosema B, de Beer F, Gangadin S, Geraets C, van ‘t Hag E, Haveman Y, van der Heijden I, Voppel A, Willemse E, van Amelsvoort T, Bak M, Batalla A, Been A, van den Bosch M, van den Brink T, Faber G, Grootens K, de Jonge M, Knegtering R, Kurkamp J, Mahabir A, Pijnenborg G, Staring T, Veen N, Veerman S, Wiersma S, Graveland E, Hoornaar J, Sommer I. Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis. Psychological Medicine 2021, 53: 2317-2327. PMID: 34664546, PMCID: PMC10123843, DOI: 10.1017/s0033291721004153.Peer-Reviewed Original ResearchConceptsDistinct cognitive subgroupsCognitive subgroupsFirst-episode psychosisDiscrete cognitive profilesGeneral functioningTrend-level effectsCognitive profileSelf-reported functional outcomesCognitive clustersCognitive deficitsCognitionBrief assessmentFunctional outcomeLarge sampleFEP patientsClinical outcomesCurrent resultsSevere clinical symptomsPsychosisEarly identificationHealthy controlsCluster analysisClinical symptomsFunctioningDeficitsExamining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study
Fusar-Poli L, Pries LK, van Os J, Erzin G, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşoğlu C, Üçok A, Alptekin K, Saka MC, investigators G, Aguglia E, Arango C, O'Donovan M, Rutten B, Guloksuz S. Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2021, 113: 110440. PMID: 34536513, DOI: 10.1016/j.pnpbp.2021.110440.Peer-Reviewed Original ResearchConceptsDegraded Facial Affect Recognition TaskFacial emotion recognitionEmotion recognitionFacial affect recognition taskAffect recognition taskSocial cognition impairmentsFER deficitsIndividual emotionsPRS-SCZFER accuracyRecognition taskHealthy controlsSchizotypy-RevisedCognition impairmentIntermediate phenotypesPsychosis riskStructured interviewsEUGEI studySchizophreniaTotal scoreSiblingsGenetic riskDifferent patternsPsychosisEmotionsSchizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Wittchen H, Rutten B, Guloksuz S. Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis. Schizophrenia Bulletin 2021, 47: 594-603. PMID: 33693921, PMCID: PMC8084443, DOI: 10.1093/schbul/sbab019.Peer-Reviewed Original ResearchConceptsFixed-effects modelCannabis usePsychotic experiencesGeneral population cohortRandom-effects modelMental health outcomesRisk factorsTime-varying confoundersProspective associationsPopulation cohortHealth outcomesOwn controlCausal associationPsychosisCannabisLongitudinal studyAssociationBetween-person levelConfoundersCohortIncidenceSchizophrenia
2020
Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. Psychological Medicine 2020, 52: 1910-1922. PMID: 33070791, DOI: 10.1017/s0033291720003748.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersChildhood adversityRisk factorsNEMESIS-2Affective dysregulationNon-genetic risk factorsSignificant depressive symptomsSample of patientsRepresentative general population sampleGenetic risk factorsGeneral population sampleSchizophrenia polygenic riskPsychosis outcomesSpectrum disorderDepressive symptomsPRS-SZPolygenic riskDysregulationPatientsPopulation samplePsychosisAffective pathwayDisordersHallucinatory experiencesDelusional ideation
2019
O6.7. TESTING THE HIGH RISK AND TRANSITION FRAMEWORK IN THE GENERAL POPULATION: POPULATION-BASED MEASURES OF RISK AND TRANSITION FOR PSYCHOSIS 6-YEAR LONGITUDINAL FOLLOW-UP
Pries L, Guloksuz S, Have M, de Graaf R, van Dorsselaer S, Rutten B, Van Os J. O6.7. TESTING THE HIGH RISK AND TRANSITION FRAMEWORK IN THE GENERAL POPULATION: POPULATION-BASED MEASURES OF RISK AND TRANSITION FOR PSYCHOSIS 6-YEAR LONGITUDINAL FOLLOW-UP. Schizophrenia Bulletin 2019, 45: s178-s178. PMCID: PMC6455329, DOI: 10.1093/schbul/sbz021.223.Peer-Reviewed Original Research
2018
Recurrent Neural Networks in Mobile Sampling and Intervention
Koppe G, Guloksuz S, Reininghaus U, Durstewitz D. Recurrent Neural Networks in Mobile Sampling and Intervention. Schizophrenia Bulletin 2018, 45: 272-276. PMID: 30496527, PMCID: PMC6403085, DOI: 10.1093/schbul/sby171.Peer-Reviewed Original ResearchConceptsRecurrent neural networkEcological momentary interventionsEveryday life contextPsychological processesMomentary interventionsData modalitiesDifferent data modalitiesSocial outcomesSocioenvironmental factorsFuture researchMultiple data modalitiesNeural networkTreatment of psychosisOnline feedbackIndividual trajectoriesPsychosisDaily lifeContext-specific interventionsInterventionEmotionsCognitionExperienceStatistical machineContextFitness trackersReasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population
Reininghaus U, Rauschenberg C, Have M, de Graaf R, van Dorsselaer S, Simons CJP, Gunther N, Pries LK, Guloksuz S, Radhakrishnan R, Bak M, van Os J. Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population. Psychological Medicine 2018, 49: 1799-1809. PMID: 30160228, DOI: 10.1017/s0033291718002209.Peer-Reviewed Original ResearchConceptsComposite International Diagnostic InterviewAffective disturbancesPsychotic experiencesNetherlands Mental Health SurveySecond Netherlands Mental Health SurveyTransdiagnostic phenotypeJTC biasMental Health SurveyDose-response relationshipGeneral population sampleHealth SurveyGeneral populationIncidence studyHelp-seeking behaviorDiagnostic InterviewTime pointsMemory performanceConclusions reasoning biasPopulation sampleRecent findingsPhenotypeDigit span taskIndividualsFindingsPsychosisT115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION
Rauschenberg C, Reininghaus U, Have M, de Graaf R, van Dorsselaer S, Gunther N, Pries L, Guloksuz S, Radhakrishnan R, Bak M, van Os J. T115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION. Schizophrenia Bulletin 2018, 44: s160-s161. PMCID: PMC5888643, DOI: 10.1093/schbul/sby016.391.Peer-Reviewed Original ResearchComposite International Diagnostic InterviewHelp-seeking behaviorAffective disturbancesGeneral populationPsychotic experiencesTransdiagnostic phenotypeNetherlands Mental Health SurveyJTC biasSecond Netherlands Mental Health SurveyMental Health SurveyRepresentative general population sampleDose-response relationshipGeneral population sampleMemory performanceSocio-demographic characteristicsRisk factorsHealth SurveyIncidence studySocio-environmental factorsDiagnostic InterviewCognitive deficitsMental healthSymptom domainsTime pointsPsychosis
2015
Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology
Guloksuz S, van Nierop M, Lieb R, van Winkel R, Wittchen H, van Os J. Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychological Medicine 2015, 45: 2389-2401. PMID: 25804288, DOI: 10.1017/s0033291715000380.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdult Survivors of Child Adverse EventsDiagnostic and Statistical Manual of Mental DisordersEnvironmental ExposureFemaleGermanyHelp-Seeking BehaviorHumansMaleModels, PsychologicalMood DisordersObsessive-Compulsive DisorderPsychopathologyPsychotic DisordersRisk FactorsSeverity of Illness IndexSubstance-Related DisordersUrban PopulationYoung AdultConceptsNon-psychotic disordersNon-psychotic psychopathologyRisk factorsMood disordersPsychotic experiencesHelp-seeking behaviorDSM-IV mood disordersEnvironmental exposuresSevere clinical stateDose-response fashionEnvironmental risk factorsPresence of psychosisIndex of severitySubthreshold psychotic experiencesIllness severityClinical stateGeneral psychopathologyCannabis useDisordersSeverityCompulsive disorderPsychotic psychopathologyPsychosisPsychopathologyTrauma