2024
On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINE
2023
Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls
Lin B, Vermeulen J, Bolhuis K, Chang X, Schirmbeck F, van Eijk K, investigators G, Alizadeh B, Bartels-Velthuis A, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Rutten B, Guloksuz S, Luykx J, van Os J, Simons C, van Winkel R, Guloksuz S, Blankers M, van den Brink W, de Haan L, Luykx J. Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls. Psychiatry Research 2023, 323: 115143. PMID: 36948018, DOI: 10.1016/j.psychres.2023.115143.Peer-Reviewed Original ResearchConceptsHealthy controlsSmoking behaviorPsychotic symptomsSchizophrenia symptomsUnaffected siblingsProspective cohort studySix-year followMental health symptomsSymptom dimensionsCohort studyRisk factorsDepressive symptomsPsychotic disordersPatientsPositive symptomsHealth symptomsNegative symptomsSimilar effect sizesSymptomsLinear mixed-effects modelsMixed-effects modelsGenetic riskMean numberPolygenic scoresOverall sample
2020
Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia
Pries L, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, Guloksuz S. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia. JAMA Psychiatry 2020, 77: 1296-1304. PMID: 32805017, PMCID: PMC7711318, DOI: 10.1001/jamapsychiatry.2020.2304.Peer-Reviewed Original ResearchConceptsRecent stressful life eventsStressful life eventsAssociations of SLEsPoor physical healthMental health outcomesHealth outcomesPhysical healthGeneral populationPopulation-based prospective cohort studyPRS-SCZNetherlands Mental Health SurveyES-SCZMental healthProspective cohort studyIncidence Study-2Modifiable environmental factorsAdulthood stressful life eventsMental Health SurveyDutch general populationPoor mental healthPopulation-based health outcomesLife eventsCohort studyMean ageHealth SurveyM126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY
Pries L, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Li B, Luykx J, Rutten B, van Os J, Guloksuz S. M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY. Schizophrenia Bulletin 2020, 46: s183-s183. PMCID: PMC7234581, DOI: 10.1093/schbul/sbaa030.438.Peer-Reviewed Original ResearchAdult stressful life eventsAssociations of SLEsStressful life eventsGeneral populationPhysical healthMental healthHealth SurveyHealth outcomesShort Form-36 Health SurveyNetherlands Mental Health SurveyImpact of SLEsRecent stressful life eventsProspective cohort studyPrevious health statusMental Health SurveyDutch general populationLife eventsCohort studyProspective surveyPolygenic risk scoresRisk scoreGene-environment interactionsGenetic predispositionHealth statusSchizophrenia