2020
Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder
Atagun M, Drukker M, Hall M, Altun I, Tatli S, Guloksuz S, van Os J, van Amelsvoort T. Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder. Psychiatry Research Neuroimaging 2020, 300: 111078. PMID: 32361172, DOI: 10.1016/j.pscychresns.2020.111078.Peer-Reviewed Original ResearchConceptsP50 sensory gatingFirst-degree relativesBipolar disorderSensory gatingP50 sensory gating deficitsDual-click paradigmFirst-episode psychosisSensory gating functionSensory gating deficitsS1-S2 differenceEffect of diagnosisAuditory P50 sensory gatingSensory gating ratiosGating deficitsInclusion criteriaTreatment statusLongitudinal courseIllness statePoor real-world functioningLiterature searchSchizophreniaDisordersRedundant sensory inputsTrend levelNeurophysiological measures
2019
Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
van Os J, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study. Psychological Medicine 2019, 50: 1884-1897. PMID: 31414981, DOI: 10.1017/s003329171900196x.Peer-Reviewed Original ResearchConceptsPsychotic disordersPolygenic riskSchizophrenia polygenic riskGene-environment interactionsGenetic riskRelatives of patientsFirst-degree relativesPsychosis phenotypeAverage genetic riskIntermediate phenotypesHealthy siblingsCognitive intermediate phenotypesControl groupAnalysis of associationAverage riskPatients
2017
Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience
van Os J, van der Steen Y, Islam M, Gülöksüz S, Rutten B, Simons C. Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine 2017, 47: 2421-2437. PMID: 28436345, DOI: 10.1017/s0033291717000915.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresHealthy comparison subjectsPsychotic disordersAttribution of salienceAffective episodesComparison subjectsIntelligence quotientTotal scorePolygenic riskFirst-degree relativesElevated genetic riskLower intelligence quotientManic episodesHealthy relativesRisk scoreNeurodevelopmental alterationsDepression subscaleLifetime ratesSimilar associationPsychosis riskFloor effectsGenetic riskPositive subscalePsychosis phenotypeDisorders
2015
Temperament characteristics in patients with panic disorder and their first-degree relatives
Altınbaş G, Altınbaş K, Gülöksüz S, Gülöksüz S, Aydemir Ö, Özgen G. Temperament characteristics in patients with panic disorder and their first-degree relatives. Comprehensive Psychiatry 2015, 60: 73-77. PMID: 25967357, DOI: 10.1016/j.comppsych.2015.03.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesHealthy controlsPanic disorderIrritable temperament scoresPanic Agoraphobia ScaleAnxious temperament scoresTemperament characteristicsTrait Anxiety InventoryClinical characteristicsPatient groupClinical conditionsSan Diego AutoquestionnairePatientsTemperament scoresTrait markerAgoraphobia ScaleAnxiety disordersProspective designDisordersStudy sampleHeritable anxiety disordersAnxiety InventoryTemperament EvaluationEducation levelIntermediate phenotypes