2022
Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm
Cavaliere F, Gülöksüz S. Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm. Npj Mental Health Research 2022, 1: 20. PMID: 38609523, PMCID: PMC10956007, DOI: 10.1038/s44184-022-00018-3.Peer-Reviewed Original ResearchModeling environment through a general exposome factor in two independent adolescent cohorts
Moore T, Visoki E, Argabright S, Didomenico G, Sotelo I, Wortzel J, Naeem A, Gur R, Gur R, Warrier V, Guloksuz S, Barzilay R. Modeling environment through a general exposome factor in two independent adolescent cohorts. Exposome 2022, 2: osac010. PMID: 36606125, PMCID: PMC9798749, DOI: 10.1093/exposome/osac010.Peer-Reviewed Original ResearchExposome factorsOverall psychopathologyAdolescent cohortPubertal developmentEnvironmental exposuresAdvanced pubertal developmentSex-matched sampleKey health-related outcomesHealth-related outcomesCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyGeneral healthCohortPhiladelphia Neurodevelopmental CohortConsistent associationABCD studyObesityNeurodevelopmental CohortParental educationExposurePsychopathologyFactorsPhysical environmental stimuli
2018
The Complexities of Evaluating the Exposome in Psychiatry: A Data-Driven Illustration of Challenges and Some Propositions for Amendments
Guloksuz S, Rutten B, Pries L, Have M, de Graaf R, van Dorsselaer S, Klingenberg B, van Os J, Ioannidis J, Group T. The Complexities of Evaluating the Exposome in Psychiatry: A Data-Driven Illustration of Challenges and Some Propositions for Amendments. Schizophrenia Bulletin 2018, 44: 1175-1179. PMID: 30169883, PMCID: PMC6192470, DOI: 10.1093/schbul/sby118.Peer-Reviewed Original ResearchConceptsMental health outcomesHealth outcomesNetherlands Mental Health SurveyMental Health SurveyPre-specified analysis planFalsification endpointsModifiable factorsSources of heterogeneityHealth SurveyIntervention effectsSelective reportingAnalysis planP-valueOutcomesEffect sizeVibration of effectsAnalytical planSame outcomeDifferent studiesExploratory analysisExposureStudy 2 dataP-value threshold