2023
T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS
Zhang Y, Gülöksüz S, Stehouwer C, Greevenbroek M, Köhler S, Eussen S, Bosma H, Boxtel M, Schram M, Linden D, Rutten B, Blokland G. T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s169-s170. DOI: 10.1016/j.euroneuro.2023.08.303.Peer-Reviewed Original ResearchPolygenic risk scoresCognitive domainsCognitive functionHeritability of cognitive functionsEffect of polygenic risk scoresEnvironmental influencesThe Maastricht StudyPotential cognitive deficitsOverall cognitive functionBrain health indexImpact cognitive healthRisk factorsGenetic predispositionGene-environment interactionsCardio-metabolic diseasesLIBRA scoresNon-adjusted modelCognitive phenotypesCognitive deficitsCognitive performanceCognitive healthLifestyle factorsOverall cognitionBrain structuresMental health
2021
Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis
Oomen P, Begemann M, Brand B, de Haan L, Veling W, Koops S, van Os J, Smit F, Bakker P, van Beveren N, Boonstra N, Gülöksüz S, Kikkert M, Lokkerbol J, Marcelis M, Rosema B, de Beer F, Gangadin S, Geraets C, van ‘t Hag E, Haveman Y, van der Heijden I, Voppel A, Willemse E, van Amelsvoort T, Bak M, Batalla A, Been A, van den Bosch M, van den Brink T, Faber G, Grootens K, de Jonge M, Knegtering R, Kurkamp J, Mahabir A, Pijnenborg G, Staring T, Veen N, Veerman S, Wiersma S, Graveland E, Hoornaar J, Sommer I. Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis. Psychological Medicine 2021, 53: 2317-2327. PMID: 34664546, PMCID: PMC10123843, DOI: 10.1017/s0033291721004153.Peer-Reviewed Original ResearchConceptsDistinct cognitive subgroupsCognitive subgroupsFirst-episode psychosisDiscrete cognitive profilesGeneral functioningTrend-level effectsCognitive profileSelf-reported functional outcomesCognitive clustersCognitive deficitsCognitionBrief assessmentFunctional outcomeLarge sampleFEP patientsClinical outcomesCurrent resultsSevere clinical symptomsPsychosisEarly identificationHealthy controlsCluster analysisClinical symptomsFunctioningDeficits
2018
T115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION
Rauschenberg C, Reininghaus U, Have M, de Graaf R, van Dorsselaer S, Gunther N, Pries L, Guloksuz S, Radhakrishnan R, Bak M, van Os J. T115. REASONING BIAS, WORKING MEMORY PERFORMANCE, AND A TRANSDIAGNOSTIC PHENOTYPE OF AFFECTIVE DISTURBANCES AND PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION. Schizophrenia Bulletin 2018, 44: s160-s161. PMCID: PMC5888643, DOI: 10.1093/schbul/sby016.391.Peer-Reviewed Original ResearchComposite International Diagnostic InterviewHelp-seeking behaviorAffective disturbancesGeneral populationPsychotic experiencesTransdiagnostic phenotypeNetherlands Mental Health SurveyJTC biasSecond Netherlands Mental Health SurveyMental Health SurveyRepresentative general population sampleDose-response relationshipGeneral population sampleMemory performanceSocio-demographic characteristicsRisk factorsHealth SurveyIncidence studySocio-environmental factorsDiagnostic InterviewCognitive deficitsMental healthSymptom domainsTime pointsPsychosis