2024
The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study.
Üçok A, Noyan H, Gülöksüz S, Saka M, Alptekin K, Atbaşoğlu C, Akturan E, Karadayı G, Baran Tatar Z, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Şahin Cankurtaran E, Ulusoy Kaymak S, Rutten B, van Os J. The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study. Psychological Medicine 2024, 54: 2414-2425. PMID: 38606591, DOI: 10.1017/s0033291724000540.Peer-Reviewed Original ResearchNegative cognitive schemasChildhood traumaCognitive schemasPsychotic symptomsEU-GEIEmotional abuseBrief Core Schema ScalesEU-GEI studySubthreshold psychotic experiencesSubtypes of traumaChildhood emotional abuseChildhood Trauma QuestionnaireNon-clinical populationsHealthy controlsNegative schemasPositive symptomsPersecutory delusionsPsychotic experiencesSchema ScaleTrauma QuestionnaireChildhood abuseSymptom severitySchizophreniaSexual abuseAbuse
2020
Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?
Marsman A, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Luykx J, Rutten B, Guloksuz S, van Os J. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health? Schizophrenia Bulletin 2020, 46: 1353-1362. PMID: 33259628, PMCID: PMC7707067, DOI: 10.1093/schbul/sbaa086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAgedFamilyFemaleGenetic Predisposition to DiseaseHealth SurveysHumansLife Change EventsLongitudinal StudiesMaleMarijuana UseMiddle AgedMultifactorial InheritanceNetherlandsPsychotic DisordersSchizophreniaSocioeconomic FactorsUrban PopulationYoung AdultConceptsPolygenic risk scoresSchizophrenia polygenic risk scoresMental healthFamily historyNetherlands Mental Health SurveyPopulation-based studyPolygenic riskChildhood traumaMental Health SurveyMental health changesEnvironmental risk factorsGeneral mental healthPopulation mental healthGeneral population sampleSomatic painRisk factorsHealth SurveyRisk scorePRS-SZBipolar disorderEpidemiological settingsMental disordersHealth changesAttributable variationPain
2019
Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms
Pinckaers F, Rotee I, Nwosu C, Krolinski P, Smeets A, Gülöksüz S, de Jong L, Vaessen T, Damen T, Uittenboogaard A, Schäfer A, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Rutten B, van Os J, Drukker M. Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms. Social Psychiatry And Psychiatric Epidemiology 2019, 54: 1045-1054. PMID: 31209522, DOI: 10.1007/s00127-019-01711-z.Peer-Reviewed Original ResearchConceptsChildhood traumaGenetic liabilityImpact of CTSymptom Checklist-90 scoresMixed-effects linear regression analysisSubthreshold psychotic experiencesChildhood Trauma Questionnaire-Short FormExpression of psychosisGeneral population twinsQuestionnaire-Short FormPsychosis expressionMultilevel mixed-effects linear regression analysesRisk factorsPsychotic symptomsSymptom subscalesLinear regression analysisSubthreshold expressionTotal scoreStatistical significancePsychic Experience (CAPE) questionnaireRegression analysis
2018
S182. Evidence That the Polygenic Risk Score for Neuroticism Does Not Moderate the Impact of Childhood Trauma on Neuroticism: A GxE Model
Klingenberg B, Guloksuz S, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Pries L, Cinar O, Bochao L, Luykx J, van Os J, Rutten B. S182. Evidence That the Polygenic Risk Score for Neuroticism Does Not Moderate the Impact of Childhood Trauma on Neuroticism: A GxE Model. Biological Psychiatry 2018, 83: s418. DOI: 10.1016/j.biopsych.2018.02.1074.Peer-Reviewed Original Research
2011
P01-239 - The effects of childhood trauma on psychotic symptoms in bipolar disorder
Ozkose M, Guclu O, Guloksuz S, Karaca O, Yildirim B, Ince B, Erkmen H. P01-239 - The effects of childhood trauma on psychotic symptoms in bipolar disorder. European Psychiatry 2011, 26: 240. DOI: 10.1016/s0924-9338(11)71950-2.Peer-Reviewed Original ResearchYoung Mania Rating ScaleMontgomery-Asperg Depression Rating ScalePsychotic episodeBipolar patientsBipolar disorderChildhood Trauma QuestionnaireChildhood traumaPsychotic symptomsRating ScaleDuration of illnessSexual abuse scoresDepression Rating ScaleMania Rating ScaleStandard treatment planTerms of ageAbuse scoresDSM-IV-TRBakirkoy ResearchInpatient unitPatientsTraining hospitalsPhysical abuse scoresPositive symptomsTherapeutic interventionsTreatment plan