In‐hospital course of patients with heart failure with improved ejection fraction in the DELIVER trial
Pabon M, Vaduganathan M, Claggett B, Chatur S, Siqueira S, Marti‐Castellote P, de Boer R, Hernandez A, Inzucchi S, Kosiborod M, Lam C, Martinez F, Shah S, Desai A, Jhund P, McMurray J, Solomon S, Vardeny O. In‐hospital course of patients with heart failure with improved ejection fraction in the DELIVER trial. European Journal Of Heart Failure 2024 PMID: 39300780, DOI: 10.1002/ejhf.3410.Peer-Reviewed Original ResearchLeft ventricular ejection fractionCourse of patientsIn-hospital courseHF hospitalizationHeart failureIn-hospital mortalityEjection fractionClinical courseLeft ventricular ejection fraction changesLeft ventricular ejection fraction measurementsClinical course of patientsIn-hospital clinical courseRisk of clinical eventsMechanical fluid removalStandard diuretic therapyMedian follow-upVentricular ejection fractionNon-invasive ventilationIntensive care unitClinical Endpoint CommitteeTime of enrollmentMechanical circulatory supportLength of stayDiuretic therapyHFimpEFDapagliflozin and Timing of Prior Heart Failure Hospitalization A Patient-Level Meta-Analysis of DAPA-HF and DELIVER
Butt J, Jhund P, Docherty K, Claggett B, Vaduganathan M, Bachus E, Hernandez A, Lam C, Inzucchi S, Martinez F, de Boer R, Kosiborod M, Desai A, Køber L, Ponikowski P, Sabatine M, Solomon S, McMurray J. Dapagliflozin and Timing of Prior Heart Failure Hospitalization A Patient-Level Meta-Analysis of DAPA-HF and DELIVER. JACC Heart Failure 2024, 12: 1586-1599. PMID: 38573262, DOI: 10.1016/j.jchf.2024.01.018.Peer-Reviewed Original ResearchConceptsHF hospitalizationDAPA-HFHeart failureComposite of worsening HFPrimary outcomePatient-level pooled analysisRisk of adverse clinical outcomesBenefits of dapagliflozinMedian follow-upMonths of randomizationEffects of dapagliflozinAdverse clinical outcomesPrior HF hospitalizationHospital categoryPrimary endpointPrevent 1 eventClinical outcomesAbsolute benefitEffective therapyFollow-upCardiovascular deathDapagliflozinAssociated with timeHigh riskPatients