2004
A DNA polymerase β mutant from colon cancer cells induces mutations
Lang T, Maitra M, Starcevic D, Li SX, Sweasy JB. A DNA polymerase β mutant from colon cancer cells induces mutations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6074-6079. PMID: 15075389, PMCID: PMC395925, DOI: 10.1073/pnas.0308571101.Peer-Reviewed Original ResearchConceptsMisincorporation of nucleotidesK289MM proteinPol beta proteinC base substitutionMouse L cellsMutation frequencyColon cancer cellsSpontaneous mutation frequencyDNA pol betaDNA positioningLys-289Mutational targetMouse cellsAltered positioningBase substitutionsColorectal carcinomaBacterial cellsTarget sequencePol betaProteinTemplate GLambda DNANeoplastic progressionBeta protein
1997
A genetic system to identify DNA polymerase β mutator mutants
Washington S, Yoon M, Chagovetz A, Li S, Clairmont C, Preston B, Eckert K, Sweasy J. A genetic system to identify DNA polymerase β mutator mutants. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 1321-1326. PMID: 9037051, PMCID: PMC19789, DOI: 10.1073/pnas.94.4.1321.Peer-Reviewed Original ResearchConceptsMutator mutantsGenetic methodsPol betaDNA synthesisAccurate DNA synthesisDNA repair processesRat pol betaWild-type pol betaEscherichia coli DNA polymerase ISpontaneous mutation frequencyDNA polymerase IAltered fidelityDNA polymerase betaMutant proteinsDNA replicationGenetic systemMammalian cellsGenetic assaysPolymerase IMutantsDNA polymerase mutantsMutator activityPolymerase mutantsBeta enzymePolymerase beta