2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionDeveloping Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs
Zakiniaeiz Y, Peltier M, Mineur Y, Gueorguieva R, Picciotto M, Petrakis I, Cosgrove K, McKee S. Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs. Journal Of Women's Health 2023, 32: 852-857. PMID: 37585509, PMCID: PMC10457604, DOI: 10.1089/jwh.2023.0015.Peer-Reviewed Original ResearchDevelopmental trajectories of alcohol and cannabis concurrent use in a nationally representative sample of United States youths
Roberts W, Schick M, Tomko R, McRae-Clark A, Pittmann B, Gueorgieva R, McKee S. Developmental trajectories of alcohol and cannabis concurrent use in a nationally representative sample of United States youths. Drug And Alcohol Dependence 2023, 248: 109908. PMID: 37149960, PMCID: PMC10330385, DOI: 10.1016/j.drugalcdep.2023.109908.Peer-Reviewed Original ResearchTesting the efficacy of real-time fMRI neurofeedback for training people who smoke daily to upregulate neural responses to nondrug rewards
Chung Y, White R, Geier C, Johnston S, Smyth J, Delgado M, McKee S, Wilson S. Testing the efficacy of real-time fMRI neurofeedback for training people who smoke daily to upregulate neural responses to nondrug rewards. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 440-456. PMID: 36788202, DOI: 10.3758/s13415-023-01070-y.Peer-Reviewed Original ResearchConceptsNondrug rewardsNeurofeedback trainingNeural responsesReal-time fMRI neurofeedback trainingReal-time fMRI neurofeedbackReward-related brain activityReward-related brain areasFMRI neurofeedback trainingTraining runsSingle neurofeedback sessionFMRI neurofeedbackBrain responsesNeurofeedback researchBrain activityBOLD activationNeurofeedback sessionsSuch rewardsStriatal activityNeurofeedbackControl conditionRewardBrain areasMonetary incentivesRecent researchSmoking cessation
2022
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes. Nicotine & Tobacco Research 2022, 25: 1047-1051. PMID: 36107715, PMCID: PMC10077933, DOI: 10.1093/ntr/ntac215.Peer-Reviewed Original ResearchConceptsCognitive functionVerbal learningPrefrontal cortexCognitive deficitsWorse verbal learningBrain-behavior relationshipsD2R availabilityDorsolateral prefrontal cortexCognitive performanceComputerized testsTask performanceCogState batteryInhibitory controlNeurocognitive testsReceptor availabilityMesocortical dopaminePositron emission tomographyDopamine D2/3 receptor availabilityMemoryCognitionD2/3 receptor availabilityDopamine releaseSmoking variablesSubject samplesDeficitsAdverse Childhood Experiences and Pathways to Violent Behavior for Women and Men
Burke C, Ellis JD, Peltier MR, Roberts W, Verplaetse TL, Phillips S, Moore KE, Marotta PL, McKee SA. Adverse Childhood Experiences and Pathways to Violent Behavior for Women and Men. Journal Of Interpersonal Violence 2022, 38: 4034-4060. PMID: 35978533, PMCID: PMC9852029, DOI: 10.1177/08862605221113012.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesViolent behaviorChildhood experiencesViolent crimeFuture violenceViolenceLatent class analysisClass analysisBiological sexTypology groupsRepresentative sampleLow adversityCrimeExperienceWomenHigh riskFour-class modelMaltreatmentChildhood maltreatmentChildhood traumaRelationshipMenAdversityRiskCurrent findingsConsideration of sex and gender differences in addiction medication response
McKee SA, McRae-Clark AL. Consideration of sex and gender differences in addiction medication response. Biology Of Sex Differences 2022, 13: 34. PMID: 35761351, PMCID: PMC9235243, DOI: 10.1186/s13293-022-00441-3.Peer-Reviewed Original ResearchConceptsSubstance use disordersMedication developmentUse disordersMedication development researchPreventable health conditionsClinical care guidelinesPublic health burdenNational InstituteSex-stratified dataGender differencesCurrent narrative reviewDrugs of abuseMedication trialsSignificant morbidityCare guidelinesMedication responseHealth burdenAbused substancesAlcohol abuseConsideration of sexNarrative reviewIncorporation of sexDrug abuseHealth conditionsSubstance useLicit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019)
Peltier MR, Roberts W, Verplaetse TL, Burke C, Zakiniaeiz Y, Moore K, McKee SA. Licit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019). Archives Of Women's Mental Health 2022, 25: 819-827. PMID: 35737132, PMCID: PMC9359119, DOI: 10.1007/s00737-022-01244-6.Peer-Reviewed Original ResearchConceptsPast-month substance useFirst trimesterPast-year substance usePregnant womenIllicit substance useDrug useSubstance useThird trimesterCross-sectional population-based dataSignificant public health concernTrimester of pregnancyPrescription pain medicationPopulation-based dataPerinatal substance useIllicit drug useMethodsThe present studyPublic health concernMinority of womenNational surveyLicit substance usePain medicationSimilar low ratesSecond trimesterLate trimesterLicit substancesUsing machine learning to predict heavy drinking during outpatient alcohol treatment
Roberts W, Zhao Y, Verplaetse T, Moore KE, Peltier MR, Burke C, Zakiniaeiz Y, McKee S. Using machine learning to predict heavy drinking during outpatient alcohol treatment. Alcohol Clinical And Experimental Research 2022, 46: 657-666. PMID: 35420710, PMCID: PMC9180421, DOI: 10.1111/acer.14802.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeavy drinkingTreatment outcomesInvasive assessment methodsOutpatient AUD treatmentLast monthOutpatient alcohol treatmentMultisite clinical trialAccurate clinical predictionsHeavy alcohol useSex differencesBi-weekly sessionsAlcohol treatment outcomesPatient characteristicsClinical outcomesClinical trialsClinical dataStratified analysisEffective treatmentPsychiatric disordersUse disordersAUD treatmentSubstantial sex differencesAlcohol treatmentFirst monthSex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways
Mineur YS, Garcia-Rivas V, Thomas MA, Soares AR, McKee SA, Picciotto MR. Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. Psychopharmacology 2022, 239: 2041-2061. PMID: 35359158, PMCID: PMC9704113, DOI: 10.1007/s00213-022-06120-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlcohol intakeInflammatory pathwaysAlcohol drinkingStress-induced alcohol drinkingSex differencesSex-dependent effectsStress-induced alcoholEffects of stressPreclinical behavioral modelsAlcohol-dependent behaviorsMicroglial activationClinical studiesPreclinical studiesInflammatory signalingNeuronal functionAlcohol seekingIntakeFuture studiesDrinkingDifferencesAmygdalaPathwayStudyWomenSexual minority disparities in opioid and benzodiazepine misuse among adults with opioid use disorder
Struble CA, Thomas K, Stenersen MR, Moore KE, Burke C, Pittman B, McKee SA. Sexual minority disparities in opioid and benzodiazepine misuse among adults with opioid use disorder. American Journal On Addictions 2022, 31: 200-209. PMID: 35243706, PMCID: PMC9117396, DOI: 10.1111/ajad.13258.Peer-Reviewed Original ResearchConceptsPast-year alcohol use disorderAlcohol use disorderSubstance use patternsBenzodiazepine misuseUse disordersConcurrent misusePast-year misuseOpioid use disorderCo-occurring alcoholSubstance use disordersTargeted prevention effortsSexual minority disparitiesConcurrent opioidBenzodiazepine useHigher oddsOpioidsElevated riskOverdose deathsConcurrent alcoholBisexual femalesDrug usePrevention effortsSubstance useSexual minority individualsBenzodiazepines
2021
Sex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders
Peltier MR, Roberts W, Verplaetse TL, Zakiniaeiz Y, Burke C, Moore KE, McKee SA. Sex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders. Journal Of Dual Diagnosis 2021, 18: 11-20. PMID: 34965199, PMCID: PMC9086923, DOI: 10.1080/15504263.2021.2016027.Peer-Reviewed Original ResearchConceptsDrug use disordersOngoing posttraumatic stress disorderSubstance use disordersSUD/PTSDPosttraumatic stress disorderNew PTSD diagnosisImpact of sexUse disordersDiagnosis of SUDPast-year substance use disorderPTSD diagnosisConcurrent substance use disordersDiagnosis of PTSDPoor treatment outcomesNational Epidemiologic SurveyBidirectional relationshipSex-specific analysesPotential sex-specific differencesTreatment outcomesChanges in alcohol use by cannabis use status among adolescents and young adults in the United States: Emerging evidence for both substitution and complementarity
Weinberger AH, Zhu J, Levin J, Moeller SJ, McKee SA, Goodwin RD. Changes in alcohol use by cannabis use status among adolescents and young adults in the United States: Emerging evidence for both substitution and complementarity. Alcohol Clinical And Experimental Research 2021, 45: 2536-2545. PMID: 34928520, PMCID: PMC8742181, DOI: 10.1111/acer.14737.Peer-Reviewed Original ResearchConceptsDaily alcohol useCannabis useAlcohol useYoung adultsAge 12Health (NSDUH) public use data filesPublic Use Data FilePast-month cannabisLogistic regression modelsRecent cannabis useMajority of adolescentsAverage drinksRate of declineDrug useAYAsPast month alcohol useAlcohol drinksAverage alcoholAnalytic sampleCannabisRecent cannabisCannabis legalizationNational surveyUnited StatesCurrent dataSex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III
Verplaetse TL, Peltier MR, Roberts W, Burke C, Moore KE, Pittman B, McKee SA. Sex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Addictive Behaviors 2021, 123: 107055. PMID: 34311184, PMCID: PMC8419091, DOI: 10.1016/j.addbeh.2021.107055.Peer-Reviewed Original ResearchConceptsSignificant medical conditionsMedical conditionsNational Epidemiologic SurveyDSM-5 AUDRespiratory conditionsEpidemiologic SurveyAlcohol useU.S. National Epidemiologic SurveyRate of drinkingPresence of cancerAlcohol use disorderRelated Conditions-IIIHeavy alcohol useGreater health consequencesYears cancerProblematic alcohol useUse disordersOrgan systemsCancerHealth consequencesRelated conditionsEffective interventionsWomenConditions-IIISexSex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders
Peltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStress-related disordersAlcohol useMajor depressive disorderAlcohol-related disordersAlcohol use disorderPosttraumatic stress disorderStress regulation systemComplex comorbiditiesDepressive disorderProblematic alcohol useUse disordersAlcohol misuseTherapeutic potentialTrauma exposureSubstance abuseStress disorderAnxiety disordersDisordersExposure resultsProgestogensNeurosteroidsNegative affectWomenComorbiditiesMale counterpartsGender and past year serious psychological distress are associated with past year AUD: Time-varying results from the National Survey on Drug Use and Health (NSDUH; 2008–2017)
Verplaetse TL, Peltier MR, Roberts W, Pittman B, McKee SA. Gender and past year serious psychological distress are associated with past year AUD: Time-varying results from the National Survey on Drug Use and Health (NSDUH; 2008–2017). Addictive Behaviors 2021, 116: 106815. PMID: 33450666, PMCID: PMC7887085, DOI: 10.1016/j.addbeh.2020.106815.Peer-Reviewed Original Research
2020
A Randomized Controlled Trial Protocol for Engaging Distress Tolerance and Working Memory to Aid Smoking Cessation in Low Socioeconomic Status (SES) Adults
Otto MW, Zvolensky MJ, Rosenfield D, Hoyt DL, Witkiewitz K, McKee SA, Bickel WK, Smits JAJ. A Randomized Controlled Trial Protocol for Engaging Distress Tolerance and Working Memory to Aid Smoking Cessation in Low Socioeconomic Status (SES) Adults. Health Psychology 2020, 39: 815-825. PMID: 32833483, PMCID: PMC8489738, DOI: 10.1037/hea0000858.Peer-Reviewed Original ResearchConceptsDistress toleranceMindfulness interventionLow distress toleranceCessation attemptsLow socioeconomic contextExperimental medicine approachRandomized clinical trial designWorking memoryLow socioeconomic status adultsMemory capacitySmoking lapseTarget of treatmentHeightened stressTreatment refinementNicotine useQuit attemptsControlled Trial ProtocolMechanistic targetStrongest predictorSpecific vulnerabilitiesClinical trial designLow educational attainmentEducational attainmentLapseTherapeutic gainA prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States
Roberts W, Marotta PL, Verplaetse TL, Peltier MR, Burke C, Ramchandani VA, McKee SA. A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States. Drug And Alcohol Dependence 2020, 216: 108210. PMID: 32805549, PMCID: PMC7609495, DOI: 10.1016/j.drugalcdep.2020.108210.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioRisk factorsAlcohol useTobacco usersNicotine metabolismTrans-3'-HydroxycotinineWave 1Biochemical risk factorsAlcohol consumption amountCurrent tobacco usersNicotine metabolism rateAssociated health outcomesSex differencesAlcohol use outcomesCigarette smokersNicotine exposureProspective studyOdds ratioTobacco useDrinking statusHealth StudyAlcohol consumptionNicotine useMetabolite ratiosHealth outcomesChanges in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation
Peltier MR, Verplaetse TL, Roberts W, Moore K, Burke C, Marotta PL, Phillips S, Smith PH, McKee SA. Changes in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation. Biology Of Sex Differences 2020, 11: 37. PMID: 32665024, PMCID: PMC7362573, DOI: 10.1186/s13293-020-00314-7.Peer-Reviewed Original ResearchConceptsMenopausal transitionExcessive alcohol useExcessive drinkingAlcohol useRandom effects logistic regressionAlcohol-related health consequencesSuch health problemsMethodsThe present studyPresent studyConclusionsThe present studyMenopausal transition stageSex-specific factorsHigher testosterone levelsBackgroundRecent dataEstradiol levelsPostmenopausal stageSex hormonesTestosterone levelsHormonal changesOlder womenAlcoholism criteriaAlcohol abuseAlcohol consumptionWomen's healthStudy of womenCo-occurring opioid and sedative use disorder: Gender differences in use patterns and psychiatric co-morbidities in the United States
Ellis JD, Pittman BP, McKee SA. Co-occurring opioid and sedative use disorder: Gender differences in use patterns and psychiatric co-morbidities in the United States. Journal Of Substance Use And Addiction Treatment 2020, 114: 108012. PMID: 32527509, PMCID: PMC7292885, DOI: 10.1016/j.jsat.2020.108012.Peer-Reviewed Original ResearchConceptsSedative use disorderOpioid use disorderUse disordersCo-occurring opioid use disorderMeeting criteriaPsychiatric conditionsCurrent opioid use disorderCo-occurring opioidPersonality disorderRisk of overdoseLogistic regression analysisCo-occurring symptomsImplementation of treatmentPosttraumatic stress disorderSchizotypal personality disorderAntisocial personality disorderNon-medical useBaseline characteristicsDepressive disorderGender-stratified logistic regression analysesPrescription monitoringOwn prescriptionsOpioidsStress disorderNESARC-III