2023
Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Verplaetse T, Roberts W, McKee S, Cosgrove K. Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes. Frontiers In Behavioral Neuroscience 2023, 17: 1192740. PMID: 37358969, PMCID: PMC10288103, DOI: 10.3389/fnbeh.2023.1192740.Peer-Reviewed Original ResearchSex steroid hormone levelsSteroid hormone levelsLow estradiol levelsTobacco smokingSex-matched counterpartsHormone levelsFree testosteroneEstradiol levelsAmphetamine administrationR availabilityPositron emission tomography scanPrimary addictive componentEmission tomography scanDopamine D2/3 receptor availabilityEffects of nicotineSex steroid hormonesAge-matched controlsCortical brain regionsD2/3 receptor availabilityNicotinic acetylcholine receptorsSex differencesDorsolateral prefrontal cortexDrug-taking behaviorDopaminergic actionsAddictive component
2019
Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers
Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDA releasePositron emission tomographyD2R availabilityDorsolateral prefrontal cortexMale smokersFemale smokersTobacco smokingPrefrontal cortexAmphetamine-induced DA releaseAmphetamine-induced dopamine releaseCortical DA releaseMesocortical DA systemEffects of nicotineSmoking-related behaviorsMesolimbic dopamine systemLong-term abstinenceSex differencesGender-specific treatmentFemale nonsmokersTobacco smokersAmphetamine administrationDopamine releaseNeurochemical mechanismsNonsmokersSmokers
2018
Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction
Verplaetse T, Morris ED, McKee SA, Cosgrove KP. Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction. Current Opinion In Behavioral Sciences 2018, 23: 196-202. PMID: 31341936, PMCID: PMC6656369, DOI: 10.1016/j.cobeha.2018.04.004.Peer-Reviewed Original ResearchSmoking addictionNicotinic acetylcholine receptor systemReceptor systemNon-nicotine factorsRecent imaging literatureSex differencesNicotine replacement therapyDopamine receptor systemAcetylcholine receptor systemNicotine-motivated behaviorsFuture medication developmentNicotine-related reinforcementTobacco smokingImaging findingsNicotine administrationReplacement therapyDopaminergic systemNeurochemical mechanismsNicotinic acetylcholineDopamine systemMedication developmentLines of evidenceSmokingImaging literatureWomen
2017
The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study
Sandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study. Neuropsychopharmacology 2017, 43: 1052-1058. PMID: 28944773, PMCID: PMC5854798, DOI: 10.1038/npp.2017.223.Peer-Reviewed Original ResearchConceptsTobacco smokersGuanfacine treatmentPositron emission tomographyTobacco smokingDA releaseDopaminergic toneDopamine releaseAmphetamine-induced DA releaseTobacco smoking cessationCortical dopamine releaseExtrastriatal brain regionsAlpha2-adrenergic agonistExtrastriatal dopamine releaseEffect of treatmentBaseline BPNDSmoking cessationReceptor radiotracerAdrenergic agonistsPET scansAnimal modelsBrain regionsEmission tomographyPET studiesDopamine signalingSmokers
2011
Blunted vagal reactivity predicts stress-precipitated tobacco smoking
Ashare RL, Sinha R, Lampert R, Weinberger AH, Anderson GM, Lavery ME, Yanagisawa K, McKee SA. Blunted vagal reactivity predicts stress-precipitated tobacco smoking. Psychopharmacology 2011, 220: 259-268. PMID: 21938416, PMCID: PMC3260347, DOI: 10.1007/s00213-011-2473-3.Peer-Reviewed Original ResearchConceptsAd lib smokingLF/HFVagal reactivityHF-HRVAbstinent smokersVagal toneSmoking behaviorSmoking cessation outcomesHigh-frequency heart rate variabilityHigh-frequency HRVBaseline HF-HRVHeart rate variabilityScript-driven imageryAltered stress responseTobacco smokingAutonomic functionConclusionsThe current findingsCessation outcomesSympathovagal balanceSmokingRate variabilityAutonomic reactivitySmokersRelapseCurrent findingsThe role of smoking expectancies in the relationship between PTSD symptoms and smoking behavior among women exposed to intimate partner violence
Ashare RL, Weinberger AH, McKee SA, Sullivan TP. The role of smoking expectancies in the relationship between PTSD symptoms and smoking behavior among women exposed to intimate partner violence. Addictive Behaviors 2011, 36: 1333-1336. PMID: 21849230, PMCID: PMC3179791, DOI: 10.1016/j.addbeh.2011.07.022.Peer-Reviewed Original ResearchConceptsNicotine dependenceSmoking behaviorPTSD symptomsSmoking expectanciesIPV-exposed womenIntimate partner violencePTSD re-experiencing symptomsPublic health problemPTSD arousal symptomsHigh rateNegative health consequencesTobacco smokingPartner violencePTSD symptom clustersRe-experiencing symptomsHealth problemsSmokingSymptomsSymptom clustersHealth consequencesTreatment developmentCigarettesArousal symptomsWomenLast month
2010
Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK, Cosgrove KP. Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. The International Journal Of Neuropsychopharmacology 2010, 14: 389-398. PMID: 21029513, PMCID: PMC3510008, DOI: 10.1017/s1461145710001227.Peer-Reviewed Original ResearchConceptsNicotine inhalerWithdrawal symptomsReceptor occupancyTobacco smokingLow nicotine cigarettesAdministration of nicotineHigh receptor occupancyDoses of nicotineNicotinic acetylcholine receptorsInhaler useTobacco smokersBaseline scanRegular cigarettesInhalerConstant infusionAcetylcholine receptorsSPECT studiesCigarettesSymptomsBeta 2Significant decreaseNicotineSignificant differencesSmokingNAChRsSPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK. SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. Drug And Alcohol Dependence 2010, 108: 146-150. PMID: 20074869, PMCID: PMC2871672, DOI: 10.1016/j.drugalcdep.2009.12.006.Peer-Reviewed Original ResearchConceptsDrinks/occasionNicotinic acetylcholine receptorsControl nonsmokersAcetylcholine receptorsHeavy drinkersHeavy drinkingLast alcoholic beverageHeavy alcohol drinkersHeavy alcoholSingle photon emissionSeverity of drinkingEffect of ageTobacco smokingAlcohol drinkersAlcohol drinkingCommon neural substrateNonsmokersAlcohol consumptionReceptor availabilityLarger studyAlcohol drinksAlcohol use behaviorsAddictive disordersDrinkersNeural substrates