2018
Developing a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation
Oberleitner LMS, Moore KE, Verplaetse T, Roberts W, McKee SA. Developing a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation. Experimental And Clinical Psychopharmacology 2018, 26: 244-250. PMID: 29863382, PMCID: PMC5990030, DOI: 10.1037/pha0000187.Peer-Reviewed Original ResearchConceptsNicotine deprivationAd libitum smokingSmoking lapse behaviorHuman laboratory modelImagery inductionSmoking periodOnly significant differenceDaily smokersTobacco cravingMonetary reinforcementSmokingSeparate daysHuman laboratoryLapse behaviorSignificant differencesMood statesEffects of stressReduced abilityDelay periodNegative mood statesPrimary aimStress imagerySecondary goalCurrent studyNeutral imagery
2014
Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking
Wilson SJ, Delgado MR, McKee SA, Grigson PS, MacLean RR, Nichols TT, Henry SL. Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking. Cognitive, Affective, & Behavioral Neuroscience 2014, 14: 1196-1207. PMID: 24777394, PMCID: PMC4213351, DOI: 10.3758/s13415-014-0285-8.Peer-Reviewed Original ResearchConceptsNicotine-deprived smokersIndividual differencesNondrug rewardsMonetary outcomesVentral striatumReward-related brain activityMeaningful individual differencesFunctional magnetic resonance imagingReward-motivated behaviorsLarge individual differencesVentral striatal responsePoor smoking cessation outcomesSmoking cessation outcomesNondrug incentivesReward devaluationNeural responsesStriatal responsesNeurobiological mechanismsBrain activityNeurobiological responsesCessation outcomesRewardMonetary reinforcementIndividual variabilityClinical implications
2012
Developing and Validating a Human Laboratory Model to Screen Medications for Smoking Cessation
McKee SA, Weinberger AH, Shi J, Tetrault J, Coppola S. Developing and Validating a Human Laboratory Model to Screen Medications for Smoking Cessation. Nicotine & Tobacco Research 2012, 14: 1362-1371. PMID: 22492085, PMCID: PMC3482010, DOI: 10.1093/ntr/nts090.Peer-Reviewed Original ResearchConceptsSubsequent ad libitum smokingSmoking cessation medicationsAd libitum smokingCessation medicationsNicotine deprivationSmoking cessationNovel smoking cessation medicationsRatings of cravingSmoking lapse behaviorHuman laboratory modelSecondary outcomesClinical efficacyClinical findingsFirst cigaretteMedication effectsSmokingMedication developmentCigarette effectsMedicationsLapse behaviorSmoking lapseTranslational toolScreen medicationsMonetary reinforcementTranslational work
2010
Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
McKee SA, Sinha R, Weinberger AH, Sofuoglu M, Harrison E, Lavery M, Wanzer J. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Journal Of Psychopharmacology 2010, 25: 490-502. PMID: 20817750, PMCID: PMC3637660, DOI: 10.1177/0269881110376694.Peer-Reviewed Original ResearchConceptsSelf-administration sessionsFirst cigaretteTobacco cravingNovel human laboratory modelAdrenal (HPA) axis reactivitySmoking lapse behaviorHuman laboratory modelImpact of stressNegative emotionsTobacco relapseDaily smokersSubsequent smokingImagery inductionAxis reactivitySmokingSubjects designSeparate daysPhysiologic reactivityMonetary reinforcementLapse behaviorTopography systemRelapseGreater satisfactionReduced abilityStress inductionNicotine and food deprivation decrease the ability to resist smoking
Leeman RF, O’Malley S, White MA, McKee SA. Nicotine and food deprivation decrease the ability to resist smoking. Psychopharmacology 2010, 212: 25-32. PMID: 20585761, PMCID: PMC3111597, DOI: 10.1007/s00213-010-1902-z.Peer-Reviewed Original ResearchConceptsSubsequent ad libitum smokingNicotine deprivationAd libitum smokingFood deprivationSmoking lapse behaviorSelf-administration periodEffect of foodSmokers' abilityMore cigarettesFirst cigaretteHuman laboratory paradigmDaily smokersTobacco cravingFood intakeCessation failureSmokingConclusionsThese findingsFood cuesMonetary reinforcementCigarettesNicotineSex differencesDeprivationLaboratory sessionsOutcomes