2019
Pharmacokinetics and Pharmacodynamics of Immediate-Release Versus Extended-Release Guanfacine in Adult Daily Smokers.
Verplaetse TL, Roberts W, Moore KE, Peltier MR, Oberleitner LM, McKee SA. Pharmacokinetics and Pharmacodynamics of Immediate-Release Versus Extended-Release Guanfacine in Adult Daily Smokers. Journal Of Clinical Psychopharmacology 2019, 39: 124-128. PMID: 30707118, PMCID: PMC6391212, DOI: 10.1097/jcp.0000000000001004.Peer-Reviewed Original ResearchConceptsAdult daily smokersDoses of guanfacineAdverse eventsMedication levelsDaily smokersTobacco cravingTreatment-emergent adverse eventsExtended-release formulationSimilar pharmacokinetic profileAttention deficit hyperactivity disorderDry mouthLast doseMigraine prophylaxisBlood pressureHeroin withdrawalStable dosingDose equivalencyHeart rateER formulationSmoking outcomesGuanfacinePharmacokinetic profileDrug AdministrationVital signsHyperactivity disorder
2018
Developing a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation
Oberleitner LMS, Moore KE, Verplaetse T, Roberts W, McKee SA. Developing a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation. Experimental And Clinical Psychopharmacology 2018, 26: 244-250. PMID: 29863382, PMCID: PMC5990030, DOI: 10.1037/pha0000187.Peer-Reviewed Original ResearchConceptsNicotine deprivationAd libitum smokingSmoking lapse behaviorHuman laboratory modelImagery inductionSmoking periodOnly significant differenceDaily smokersTobacco cravingMonetary reinforcementSmokingSeparate daysHuman laboratoryLapse behaviorSignificant differencesMood statesEffects of stressReduced abilityDelay periodNegative mood statesPrimary aimStress imagerySecondary goalCurrent studyNeutral imagery
2016
Guanfacine alters the effect of stress and smoking on heart rate variability in regular daily smokers
Verplaetse TL, Smith PH, Smith KM, Oberleitner LM, McKee SA. Guanfacine alters the effect of stress and smoking on heart rate variability in regular daily smokers. Psychopharmacology 2016, 234: 805-813. PMID: 28028603, PMCID: PMC5309140, DOI: 10.1007/s00213-016-4517-1.Peer-Reviewed Original ResearchConceptsHeart rate variabilityRegular daily smokersEffects of guanfacineSmoking lapse behaviorHF-HRVPlacebo groupDaily smokersRate variabilitySmoking-related decreaseΑ2A-adrenergic agonistAd libitum smokingAd lib smokingHigh-frequency heart rate variabilityEffects of stressStress imageryNoradrenergic targetsVagal activityParent studySmokingGuanfacineTonic levelsPhasic changesNeutral imagery conditionsPotential mechanismsImportant marker
2015
Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample
Lewis AS, Oberleitner LM, Morgan PT, Picciotto MR, McKee SA. Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample. Nicotine & Tobacco Research 2015, 18: 1456-1462. PMID: 26718905, PMCID: PMC5942535, DOI: 10.1093/ntr/ntv287.Peer-Reviewed Original ResearchConceptsCigarette smoking statusSmoking statusCigarette smokingSelf-directed violenceRisk factorsDaily smokersViolence risk assessmentWave 1Substance useFormer cigarette smokersFormer daily smokersDaily cigarette smokingMajor risk factorNational Epidemiological SurveyCommunity-based sampleLogistic regression modelsRelevant demographic covariatesViolence risk factorsCessation strategiesCigarette smokersPsychiatric diagnosisEpidemiological surveySmokersSmokingAdult subjectsCorrelates of smoking status among women experiencing intimate partner violence: Substance use, posttraumatic stress, and coping
Sullivan TP, Flanagan JC, Dudley DN, Holt LJ, Mazure CM, McKee SA. Correlates of smoking status among women experiencing intimate partner violence: Substance use, posttraumatic stress, and coping. American Journal On Addictions 2015, 24: 546-553. PMID: 26249027, PMCID: PMC4600351, DOI: 10.1111/ajad.12261.Peer-Reviewed Original ResearchConceptsSymptom severitySmoking statusIntimate partner violenceAlcohol problem severityPopulation of womenProblem severityDaily smoking statusIPV-victimized womenPsychiatric symptom severityCessation interventionsCigarette smokingDaily smokersPartner violencePhysical intimate partner violenceSeverity of useCessation researchWomen's healthPosttraumatic stress symptom severityStress symptom severityDrug useNegative sequelaeContext of IPVLogistic regressionSmokersSeverity
2014
Stability of smoking status in the US population: a longitudinal investigation
Weinberger AH, Pilver CE, Mazure CM, McKee SA. Stability of smoking status in the US population: a longitudinal investigation. Addiction 2014, 109: 1541-1553. PMID: 24916157, PMCID: PMC4127136, DOI: 10.1111/add.12647.Peer-Reviewed Original ResearchConceptsCurrent daily smokersDaily smokersSmoking statusSmoking cessationSmoking transitionsGeneral US adult populationNon-daily smokersFormer daily smokersUS adult populationNational Epidemiologic SurveyWave 1Daily smokingUS adultsSmokersEpidemiologic SurveyHispanic adultsUS populationAdult populationRelated conditionsOlder adultsLess educationAdultsLongitudinal studySmokingIntervention efforts
2013
Changes in Smoking for Adults with and without Alcohol and Drug Use Disorders: Longitudinal Evaluation in the US Population
Weinberger AH, Pilver CE, Hoff RA, Mazure CM, McKee SA. Changes in Smoking for Adults with and without Alcohol and Drug Use Disorders: Longitudinal Evaluation in the US Population. The American Journal Of Drug And Alcohol Abuse 2013, 39: 186-193. PMID: 23721534, PMCID: PMC3696891, DOI: 10.3109/00952990.2013.785557.Peer-Reviewed Original ResearchConceptsCurrent drug use disordersDrug use disordersCurrent alcohol use disorderAlcohol use disorderDUD diagnosesUse disordersSmoking cessationDaily smokersSmoking relapsePast alcohol use disordersFormer daily smokersCurrent daily smokersUS adult populationDaily cigarette smokersAssessment 3 yearsNational Epidemiologic SurveyWave 2Gender-specific effectsCigarette smokersEpidemiologic SurveyDiagnosis interactionRelapse behaviorSmokingUS populationAdult population
2012
The relationship of dysthymia, minor depression, and gender to changes in smoking for current and former smokers: Longitudinal evaluation in the U.S. population
Weinberger AH, Pilver CE, Desai RA, Mazure CM, McKee SA. The relationship of dysthymia, minor depression, and gender to changes in smoking for current and former smokers: Longitudinal evaluation in the U.S. population. Drug And Alcohol Dependence 2012, 127: 170-176. PMID: 22809897, PMCID: PMC3480998, DOI: 10.1016/j.drugalcdep.2012.06.028.Peer-Reviewed Original ResearchConceptsFormer daily smokersCurrent daily smokersCurrent dysthymiaMinor depressionLifetime dysthymiaDaily smokersFormer smokersSmoking behaviorDaily cigarette smokersNational Epidemiologic SurveyWave 2Gender-specific effectsCigarette smokersSmoking abstinenceMajor depressionSmokersEpidemiologic SurveyDysthymiaDiagnosis interactionRespective diagnosisDecreased likelihoodLongitudinal evaluationRelated conditionsSmokingDepressionTobacco Quitlines Need to Assess and Intervene with Callers' Hazardous Drinking
Toll BA, Cummings KM, O'Malley SS, Carlin‐Menter S, McKee SA, Hyland A, Wu R, Hopkins J, Celestino P. Tobacco Quitlines Need to Assess and Intervene with Callers' Hazardous Drinking. Alcohol Clinical And Experimental Research 2012, 36: 1653-1658. PMID: 22703028, PMCID: PMC3436938, DOI: 10.1111/j.1530-0277.2012.01767.x.Peer-Reviewed Original ResearchConceptsSmoking cessation ratesCessation ratesBrief alcohol interventionHazardous drinkingHigh-risk drinkersQuitline callersTobacco quitlineCessation outcomesNIAAA guidelinesAlcohol interventionsLower smoking cessation ratesModerate alcohol consumptionShort-term followQuarter of smokersHazardous drinking patternsHigh rateSmoking cessationDaily smokersModerate drinkersSmoking relapseHazardous drinkersAlcohol consumptionSmokersDrinking patternsQuitlineThe relationship of major depressive disorder and gender to changes in smoking for current and former smokers: longitudinal evaluation in the US population
Weinberger AH, Pilver CE, Desai RA, Mazure CM, McKee SA. The relationship of major depressive disorder and gender to changes in smoking for current and former smokers: longitudinal evaluation in the US population. Addiction 2012, 107: 1847-1856. PMID: 22429388, PMCID: PMC3419319, DOI: 10.1111/j.1360-0443.2012.03889.x.Peer-Reviewed Original ResearchConceptsCurrent major depressive disorderMajor depressive disorderFormer daily smokersDepressive disorderFormer smokersNational Epidemiologic SurveyDaily smokersWave 2Current daily smokersUnited States civilianWave 1Smoking statusNicotine dependenceSmoking relapseAlcohol abuseSmokersEpidemiologic SurveyDiagnosis interactionRespective diagnosisUS populationLongitudinal evaluationRelated conditionsSmokingLower likelihoodDistrict of ColumbiaEffects of Varenicline and Bupropion on Cognitive Processes Among Nicotine-Deprived Smokers
Ashare RL, McKee SA. Effects of Varenicline and Bupropion on Cognitive Processes Among Nicotine-Deprived Smokers. Experimental And Clinical Psychopharmacology 2012, 20: 63-70. PMID: 21942262, PMCID: PMC3640636, DOI: 10.1037/a0025594.Peer-Reviewed Original ResearchConceptsNicotine deprivationCognitive processesMeasures of attentionNicotine-deprived smokersMeasures of cravingEffects of vareniclineNegative affectOvernight abstinenceCurrent data highlightMemoryReduced accuracyDaily smokersCurrent sampleDifficulty concentratingLaboratory sessionsEffects of bupropionFuture researchReaction timeSex differencesRecent researchAbstinence ratesDeficitsNew pharmacological treatmentsParticipantsSmoking cessation
2010
Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
McKee SA, Sinha R, Weinberger AH, Sofuoglu M, Harrison E, Lavery M, Wanzer J. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Journal Of Psychopharmacology 2010, 25: 490-502. PMID: 20817750, PMCID: PMC3637660, DOI: 10.1177/0269881110376694.Peer-Reviewed Original ResearchConceptsSelf-administration sessionsFirst cigaretteTobacco cravingNovel human laboratory modelAdrenal (HPA) axis reactivitySmoking lapse behaviorHuman laboratory modelImpact of stressNegative emotionsTobacco relapseDaily smokersSubsequent smokingImagery inductionAxis reactivitySmokingSubjects designSeparate daysPhysiologic reactivityMonetary reinforcementLapse behaviorTopography systemRelapseGreater satisfactionReduced abilityStress inductionNicotine and food deprivation decrease the ability to resist smoking
Leeman RF, O’Malley S, White MA, McKee SA. Nicotine and food deprivation decrease the ability to resist smoking. Psychopharmacology 2010, 212: 25-32. PMID: 20585761, PMCID: PMC3111597, DOI: 10.1007/s00213-010-1902-z.Peer-Reviewed Original ResearchConceptsSubsequent ad libitum smokingNicotine deprivationAd libitum smokingFood deprivationSmoking lapse behaviorSelf-administration periodEffect of foodSmokers' abilityMore cigarettesFirst cigaretteHuman laboratory paradigmDaily smokersTobacco cravingFood intakeCessation failureSmokingConclusionsThese findingsFood cuesMonetary reinforcementCigarettesNicotineSex differencesDeprivationLaboratory sessionsOutcomes
2009
Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders
Weinberger AH, Desai RA, McKee SA. Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders. Drug And Alcohol Dependence 2009, 108: 7-12. PMID: 20006451, PMCID: PMC2835820, DOI: 10.1016/j.drugalcdep.2009.11.004.Peer-Reviewed Original ResearchConceptsSubstance use disordersCurrent mood disorderAlcohol use disorderCo-morbid psychiatric disordersTobacco withdrawal symptomsWithdrawal symptomsPsychiatric disordersMood disordersUse disordersNicotine withdrawalAnxiety disordersCurrent Axis I disordersCurrent daily smokersCurrent psychiatric disorderAxis I DisordersMore withdrawal symptomsWithdrawal-related symptomsNational Epidemiologic SurveyLogistic regression modelsPrevent relapseDaily smokersI disordersU.S. smokersAxis ICurrent disorderNicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention
Harrison EL, Coppola S, McKee SA. Nicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention. Experimental And Clinical Psychopharmacology 2009, 17: 91-98. PMID: 19331485, PMCID: PMC2863308, DOI: 10.1037/a0015657.Peer-Reviewed Original ResearchConceptsCognitive processingNicotine deprivationImpulsive smokersTrait impulsivityGo/No-Go taskBarratt Impulsiveness ScaleCognitive tasksInhibitory controlPerformance decrementsImpulsiveness ScaleTask IISubjects designImpulsivityGreater impairmentDaily smokersReaction timeDeprivation conditionsMixed model regression analysisTaskProcessingRelapse riskImpairmentSignificant deprivationImpulsivenessDeprivationVarenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers
McKee SA, Harrison EL, O'Malley SS, Krishnan-Sarin S, Shi J, Tetrault JM, Picciotto MR, Petrakis IL, Estevez N, Balchunas E. Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers. Biological Psychiatry 2009, 66: 185-190. PMID: 19249750, PMCID: PMC2863311, DOI: 10.1016/j.biopsych.2009.01.029.Peer-Reviewed Original ResearchConceptsHeavy drinking smokersSelf-administration periodAlcohol consumptionPartial nicotinic agonistPlacebo-controlled investigationEffects of vareniclineReduced ethanol intakeAlcohol Self-AdministrationAlcohol use disorderNicotinic acetylcholine receptorsMedication pretreatmentAdverse eventsNumber of drinksPreclinical evidenceAdditional drinkEthanol intakeTobacco dependenceDaily smokersPriming doseVareniclineComorbid disordersNicotinic agonistsUse disordersPriming drinkPotential treatmentExperimenting and daily smokers: Episodic patterns of alcohol and cigarette use
Harrison EL, Hinson RE, McKee SA. Experimenting and daily smokers: Episodic patterns of alcohol and cigarette use. Addictive Behaviors 2009, 34: 484-486. PMID: 19176271, PMCID: PMC2865434, DOI: 10.1016/j.addbeh.2008.12.013.Peer-Reviewed Original ResearchConceptsCigarette useEpisodic patternPatterns of alcoholBinge levelsConsumption of drinksSmoking historyCigarette smokingTobacco dependenceDaily smokersNicotine dependenceSmoking episodesConcurrent alcoholSmokersSmokingMore drinksAlcohol useGroup differencesDrinksTypical drinkingDrinkingTotal numberHoursSelf-reported pleasureCigarettesCollege-age sample
2008
Nondaily Smoking and Alcohol Use, Hazardous Drinking, and Alcohol Diagnoses Among Young Adults: Findings From the NESARC
Harrison EL, Desai RA, McKee SA. Nondaily Smoking and Alcohol Use, Hazardous Drinking, and Alcohol Diagnoses Among Young Adults: Findings From the NESARC. Alcohol Clinical And Experimental Research 2008, 32: 2081-2087. PMID: 18828805, PMCID: PMC2626157, DOI: 10.1111/j.1530-0277.2008.00796.x.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDSM-IV alcohol diagnosesHazardous drinkingDaily smokersUse disordersAlcohol useYoung adultsNondaily smokersAlcohol diagnosisDaily binge drinkingCigarette use patternsNational Epidemiologic SurveyCurrent smoking behaviorDrinking behaviorHeavy alcohol useAlcohol use patternsCurrent smokersBinge drinking behaviorSmoking statusDaily smokingNondaily smokingCurrent drinkersMultinomial logistic regressionBinge drinkingSmokersCorrespondence of Interactive Voice Response (IVR) Reports of Nicotine Withdrawal, Craving, and Negative Mood with Questionnaire Ratings
Toll BA, Cooney JL, McKee SA, O'Malley SS, Cooney NL. Correspondence of Interactive Voice Response (IVR) Reports of Nicotine Withdrawal, Craving, and Negative Mood with Questionnaire Ratings. Nicotine & Tobacco Research 2008, 10: 1057-1064. PMID: 18584469, PMCID: PMC2791461, DOI: 10.1080/14622200802097498.Peer-Reviewed Original ResearchConceptsNicotine withdrawalDepressive symptomsSmoking cessation trialCessation trialDaily smokersInteractive voice response systemVoice response systemDaily assessmentCravingWeeksNegative moodWithdrawalSymptomsPaper questionnaireQuestionnaire ratingsReportFuture studiesQuestionnaireIVR systemMoodDaysSample sizeDaily reportsSmokersSmokingRelationship of perceived risks of smoking cessation to symptoms of withdrawal, craving, and depression during short-term smoking abstinence
Weinberger AH, Krishnan-Sarin S, Mazure CM, McKee SA. Relationship of perceived risks of smoking cessation to symptoms of withdrawal, craving, and depression during short-term smoking abstinence. Addictive Behaviors 2008, 33: 960-963. PMID: 18384974, PMCID: PMC2442160, DOI: 10.1016/j.addbeh.2008.02.013.Peer-Reviewed Original ResearchConceptsShort-term smoking abstinenceShort-term abstinenceSelf-reported experiencesExperienced withdrawal symptomsWithdrawal symptomsBehavioral interventionsSmoking cessationContingency managementCravingRisk beliefsSmoking abstinenceDaily smokersHigh levelsRelationship of riskRisk perceptionNicotine dependenceAbstinenceParticipantsCurrent studySymptoms of withdrawalDepressionBaseline smokingRisk groupsSymptomsRelationship