2012
Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide
Wallis RS, Jakubiec W, Mitton-Fry M, Ladutko L, Campbell S, Paige D, Silvia A, Miller PF. Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide. PLOS ONE 2012, 7: e30479. PMID: 22279595, PMCID: PMC3261206, DOI: 10.1371/journal.pone.0030479.Peer-Reviewed Original ResearchMeSH KeywordsAdamantaneAntitubercular AgentsDiarylquinolinesDrug MonitoringDrug Therapy, CombinationEthylenediaminesExtensively Drug-Resistant TuberculosisHumansMicrobial Sensitivity TestsMycobacterium tuberculosisNitroimidazolesOxazolidinonesPyrazinamideQuinolinesReproducibility of ResultsTime FactorsConceptsPNU-100480Whole blood culturesPA-824Blood culturesWhole-blood bactericidal activityBactericidal activityStandard TB therapyDihydroxy vitamin DIntracellular M. tuberculosisBlood bactericidal activityCumulative activityPZA-resistant strainsHigh therapeutic concentrationsActive regimensTB regimensNew regimensTB therapyVitamin DOral dosingTherapeutic concentrationsDrug combinationsPharmacokinetic dataRegimensIndividual drugsTMC207SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro
Reddy VM, Dubuisson T, Einck L, Wallis RS, Jakubiec W, Ladukto L, Campbell S, Nacy CA. SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro. Journal Of Antimicrobial Chemotherapy 2012, 67: 1163-1166. PMID: 22258923, DOI: 10.1093/jac/dkr589.Peer-Reviewed Original ResearchConceptsPNU-100480Whole blood culturesMycobacterium tuberculosisRate of killingBlood culturesOrder of efficacyChequerboard titrationIndividual drugsIntracellular M. tuberculosisIntracellular Mycobacterium tuberculosisTime-kill studiesTwo-drug interactionsIntracellular activityMtb killingJ774A.1 mouse macrophagesSQ109M. tuberculosisMajor metaboliteTuberculosisMouse macrophagesBactericidal activityDrugsEfficacyKillingMacrophages
2006
Measurement of Serum d-Arabinitol/Creatinine Ratios for Initial Diagnosis and for Predicting Outcome in an Unselected, Population-Based Sample of Patients with Candida Fungemia
Yeo SF, Huie S, Sofair AN, Campbell S, Durante A, Wong B. Measurement of Serum d-Arabinitol/Creatinine Ratios for Initial Diagnosis and for Predicting Outcome in an Unselected, Population-Based Sample of Patients with Candida Fungemia. Journal Of Clinical Microbiology 2006, 44: 3894-3899. PMID: 16957030, PMCID: PMC1698297, DOI: 10.1128/jcm.01045-06.Peer-Reviewed Original ResearchConceptsCandida fungemiaUnselected patientsCreatinine ratioInitial diagnosisMicroM/First positive blood cultureD-arabinitol/creatinine ratioHigh-risk groupSample of patientsPositive blood culturesUseful diagnostic markerFungemia patientsFungemic patientsBlood culturesPredicting OutcomePatientsFungemiaHealthy adultsDiagnostic markerPrognostic purposesMore daysSame dayC. parapsilosisEnzymatic fluorometric assayCancer