2019
Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
Maldonado MBC, de Rezende Neto NB, Nagamatsu ST, Carazzolle MF, Hoff JL, Whitacre LK, Schnabel RD, Behura SK, McKay SD, Taylor JF, Lopes FL. Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation. PLOS ONE 2019, 14: e0222329. PMID: 31513639, PMCID: PMC6742455, DOI: 10.1371/journal.pone.0222329.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCpG IslandsDatabases, GeneticDNADNA MethylationEpigenesis, GeneticEpigenomicsGenomeGenome-Wide Association StudyPolymorphism, Single NucleotideSequence Analysis, DNAConceptsSingle nucleotide polymorphismsCpG islandsDNA methylationReference genome sequence assemblyDatabase of SNPsCpG sitesBull Genomes ProjectGenome sequence assemblyDivergent feed efficiencyBovine phenotypesEpigenetic polymorphismEpigenetic controlEpigenetic regulationIntergenic regionNearby genesMethylation targetsGenomic sequencesMethylation patternsSequence assemblyGenome ProjectMethylation profilesMethylation sitesSNP databaseDifferential expressionVariant annotation
2016
Unraveling the genetic basis of xylose consumption in engineered Saccharomyces cerevisiae strains
dos Santos LV, Carazzolle MF, Nagamatsu ST, Sampaio NM, Almeida LD, Pirolla RA, Borelli G, Corrêa TL, Argueso JL, Pereira GA. Unraveling the genetic basis of xylose consumption in engineered Saccharomyces cerevisiae strains. Scientific Reports 2016, 6: 38676. PMID: 28000736, PMCID: PMC5175268, DOI: 10.1038/srep38676.Peer-Reviewed Original ResearchConceptsXylose fermentationAdaptive evolutionSecond-generation ethanol productionDevelopment of biocatalystsXylose isomerase geneRobust industrial strainsSecond-generation ethanolIron-sulfur clustersFive-carbon sugarsEngineered SaccharomycesMetabolic engineeringEssential genesEthanol productionXylose consumptionScaffold proteinRegulatory networksXylose utilizationIsomerase geneGenetic basisViable productionIndustrial strainsEthanol/Yeast cellsPentose metabolismGenes