2024
ONCOGENES AND TUMOR SUPPRESSOR GENES IN CARCINOMA EX PLEOMORPHIC ADENOMA DEVELOPMENT: OLD FACTS AND NEW HYPOTHESES.
SCARINI J, NAGAMATSU S, CARAZZOLLE M, Abu EGAL É, ALTEMANI A, CASTILHO R, MARIANO F. ONCOGENES AND TUMOR SUPPRESSOR GENES IN CARCINOMA EX PLEOMORPHIC ADENOMA DEVELOPMENT: OLD FACTS AND NEW HYPOTHESES. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2024, 137: e303. DOI: 10.1016/j.oooo.2023.12.719.Peer-Reviewed Original ResearchTumor suppressor geneWhole-exome sequencingSingle nucleotide variantsGenetic alterationsAllele frequenciesSuppressor geneHg38 reference genomeDisease allele frequencyReference genomeSequence readsNucleotide variantsExome sequencingDNA samplesMYBOncogenic activityPublic databasesPleomorphic adenomaGenesOncogenePre-existing pleomorphic adenomaPotential involvementSequenceTP53Background CarcinomaRare tumor
2021
Ethanol production process driving changes on industrial strains
Nagamatsu ST, Coutouné N, José J, Fiamenghi MB, Pereira GAG, de Castro Oliveira J, Carazzolle MF. Ethanol production process driving changes on industrial strains. FEMS Yeast Research 2021, 21: foaa071. PMID: 33417685, DOI: 10.1093/femsyr/foaa071.Peer-Reviewed Original ResearchConceptsMain evolutionary driversEthanol production processMore robust strainsStress response genesSugarcane fermentationEthanol titerEthanol RedEthanol productionEvolutionary driversIndustrial yeastIndustrial fermentationMaltose transporterGenome adaptationEngineering strategiesPhylogenetic treeCorn fermentationPositive selectionSaccharomyces cerevisiaeMetal homeostasisIndustrial strainsResponse genesBiofuel productionRobust strainsNumber of copiesGenes
2016
Unraveling the genetic basis of xylose consumption in engineered Saccharomyces cerevisiae strains
dos Santos LV, Carazzolle MF, Nagamatsu ST, Sampaio NM, Almeida LD, Pirolla RA, Borelli G, Corrêa TL, Argueso JL, Pereira GA. Unraveling the genetic basis of xylose consumption in engineered Saccharomyces cerevisiae strains. Scientific Reports 2016, 6: 38676. PMID: 28000736, PMCID: PMC5175268, DOI: 10.1038/srep38676.Peer-Reviewed Original ResearchConceptsXylose fermentationAdaptive evolutionSecond-generation ethanol productionDevelopment of biocatalystsXylose isomerase geneRobust industrial strainsSecond-generation ethanolIron-sulfur clustersFive-carbon sugarsEngineered SaccharomycesMetabolic engineeringEssential genesEthanol productionXylose consumptionScaffold proteinRegulatory networksXylose utilizationIsomerase geneGenetic basisViable productionIndustrial strainsEthanol/Yeast cellsPentose metabolismGenes