2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesApathyCognitive DysfunctionHumansMagnetic Resonance ImagingConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscoresCerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced quality
2021
Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis
Zhornitsky S, Chaudhary S, Le TM, Chen Y, Zhang S, Potvin S, Chao HH, van Dyck CH, Li CR. Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis. Psychiatry Research Neuroimaging 2021, 317: 111380. PMID: 34482052, PMCID: PMC8579376, DOI: 10.1016/j.pscychresns.2021.111380.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAlzheimer DiseaseCognitive DysfunctionDiagnosis, Dual (Psychiatry)HumansMagnetic Resonance ImagingConceptsAlcohol use disorderAlzheimer's diseaseHippocampal formationUse disordersHigher Clinical Dementia Rating Scale-SumVentricular volumeVolumetric deficitsCingulate cortexClinical Dementia Rating Scale SumCoordinating CenterSmaller hippocampal volumesLarger ventricular volumesNational Alzheimer's Coordinating CenterIsthmus cingulate cortexPosterior cingulate cortexMisuse of alcoholSuperior parietal cortexDistinct brain regionsCognitive dysfunctionHippocampal volumeInferior frontal gyrusRegional GMVHigh riskDementia severityDual diagnosis
2020
Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment
Chaudhary S, Kumaran S, Goyal V, Kalaivani M, Kaloiya G, Sagar R, Mehta N, Srivastava A, Jagannathan N. Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment. Neurological Sciences 2020, 42: 1053-1064. PMID: 32729012, DOI: 10.1007/s10072-020-04626-9.Peer-Reviewed Original ResearchMeSH KeywordsAspartic AcidBrainCognitive DysfunctionCreatineFrontal LobeGray MatterHumansMagnetic Resonance ImagingParkinson DiseaseConceptsFrontal gray matterParkinson's disease cognitive impairmentN-acetyl aspartateHealthy controlsGray matterCognitive impairmentMetabolic alterationsFrontal WMLC Model softwareProton magnetic resonance spectroscopic imagingFrontal white matter regionsCognitive biomarkersCholinergic neural transmissionPD-CN groupsMagnetic resonance spectroscopic imagingWhite matter regionsNeuro-metabolismPD dementiaFunctional impairmentPD-CIFunction lossNeural transmissionTotal creatineNormal cognitionTotal cholineCortical thickness and gyrification index measuring cognition in Parkinson’s disease
Chaudhary S, Kumaran S, Goyal V, Kaloiya G, Kalaivani M, Jagannathan N, Sagar R, Mehta N, Srivastava A. Cortical thickness and gyrification index measuring cognition in Parkinson’s disease. International Journal Of Neuroscience 2020, 131: 984-993. PMID: 32423354, DOI: 10.1080/00207454.2020.1766459.Peer-Reviewed Original ResearchMeSH KeywordsAgedCerebral CortexCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseaseConceptsHealthy controlsRegional cortical thicknessCortical thicknessGyrification indexCortical thinningDisease patientsGI reductionDesikan-Killiany atlasNormal healthy controlsPD-CNParkinson's disease patientsWidespread cortical thinningCortico-cortical connectivityClinical variablesPD-CIParkinson's diseaseDisease pathophysiologyNormal cognitionTemporal regionsROC analysisBrain surfaceAnatomical MRIBrain ROIsPatientsSuch alterationsDomain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment
Chaudhary S, Kumaran S, Kaloiya G, Goyal V, Sagar R, Kalaivani M, Jaganathan N, Mehta N, Srivastava A. Domain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment. Journal Of Clinical Neuroscience 2020, 75: 99-105. PMID: 32192853, DOI: 10.1016/j.jocn.2020.03.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedCognitive DysfunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsParkinson DiseaseConceptsMild cognitive impairmentCognitive impairmentVisuospatial functionCognitive domain specificitySpecific cognitive impairmentsCognitive Assessment testMontreal Cognitive Assessment (MoCA) testStage of MCIExecutive functionPD clinical scoresDigit spanPD-MCIPD cognitionFronto-striatalRecall domainsDomain specificityCognitive AssessmentPD groupPotential confoundsCognitionCognitive pathophysiologyCortical syndromesCategorization of subjectsMemoryNormal cognition