2023
Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults
Li G, Chen Y, Chaudhary S, Li C, Hao D, Yang L, Li C. Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults. NeuroImage 2023, 279: 120340. PMID: 37611815, DOI: 10.1016/j.neuroimage.2023.120340.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexRight insulaSymptom severityMediation analysisSleep dysfunctionWhole-brain regressionHuman Connectome Project datasetSubjective mood stateYoung adultsState functional connectivityDepression symptom severityNegative emotionsCognitive performanceEmotional deficitsEmotional statesPotential sex differencesAffective functionsDrinking severityMood statesMotivated behaviorFunctional connectivityPoor sleep qualityRSFCSleep Quality IndexSleep quality
2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscores