2024
Gray Matter Atrophy in a 6-OHDA-induced Model of Parkinson’s Disease
Kumari S, Rana B, Kumaran S, Chaudhary S, Jain S, Srivastava A, Rajan R. Gray Matter Atrophy in a 6-OHDA-induced Model of Parkinson’s Disease. Neuroscience 2024, 551: 217-228. PMID: 38843989, DOI: 10.1016/j.neuroscience.2024.05.029.Peer-Reviewed Original ResearchVolume-based morphometryGray matter volumeMachine learningMagnetic resonance imagingClassification accuracyGray matter atrophySham controlsSupport vector machine (SVM)-based algorithmContralateral rotational behaviorUnilateral 6-hydroxydopamineIncrease classification accuracyAssociated with progressionMatter volumeModel of Parkinson's diseaseParkinson's diseaseBrain regionsBasal ganglia-thalamocortical circuitsPD modelSubcortical brain regionsGMV changesGray matter volume atrophyBrain morphometric changesInternal capsuleStudy of alterationsSubstantia nigra
2022
In vitro and in vivo NMR based metabolomics in Parkinson's disease
Chaudhary S, Kumari S, Kumaran S, Goyal V, Jain S, Kaloiya G. In vitro and in vivo NMR based metabolomics in Parkinson's disease. Journal Of Magnetic Resonance Open 2022, 10: 100050. DOI: 10.1016/j.jmro.2022.100050.Peer-Reviewed Original ResearchNon-motor symptomsParkinson's diseaseMetabolic alterationsCognitive impairmentCommon non-motor symptomCerebral metabolic alterationsPathophysiological progressionPD subgroupsEarly diagnosisEarly changesDisease pathophysiologyBrain metabolitesSpecific biomarkersNeurodegenerative diseasesDiseaseMagnetic resonance spectroscopy techniquesSymptomsImpairmentAlterationsNon-invasive characterizationPathophysiologyDementiaDiagnosisProgressionBiomarkers
2020
Cortical thickness and gyrification index measuring cognition in Parkinson’s disease
Chaudhary S, Kumaran S, Goyal V, Kaloiya G, Kalaivani M, Jagannathan N, Sagar R, Mehta N, Srivastava A. Cortical thickness and gyrification index measuring cognition in Parkinson’s disease. International Journal Of Neuroscience 2020, 131: 984-993. PMID: 32423354, DOI: 10.1080/00207454.2020.1766459.Peer-Reviewed Original ResearchConceptsHealthy controlsRegional cortical thicknessCortical thicknessGyrification indexCortical thinningDisease patientsGI reductionDesikan-Killiany atlasNormal healthy controlsPD-CNParkinson's disease patientsWidespread cortical thinningCortico-cortical connectivityClinical variablesPD-CIParkinson's diseaseDisease pathophysiologyNormal cognitionTemporal regionsROC analysisBrain surfaceAnatomical MRIBrain ROIsPatientsSuch alterations
2019
Saccadic Eye Movements in Young-Onset Parkinson’s Disease - A BOLD fMRI Study
Srivastava A, Sharma R, Goyal V, Chaudhary S, Sood S, Kumaran S. Saccadic Eye Movements in Young-Onset Parkinson’s Disease - A BOLD fMRI Study. Neuro-Ophthalmology 2019, 44: 89-99. PMID: 32395155, PMCID: PMC7202441, DOI: 10.1080/01658107.2019.1652656.Peer-Reviewed Original ResearchYoung-onset Parkinson's diseaseSaccadic eye movementsFunctional magnetic resonance imagingEye movementsParkinson's diseaseLevel-dependent (BOLD) fMRISaccadic tasksFunctional imagingFrontal gyrusGroup of patientsStatistical parametric mapping softwareMedial frontal gyrusMagnetic resonance imagingOnset Parkinson's diseaseBOLD fMRI studiesParietal cortical activityMiddle frontal gyrusSaccadic circuitryControl subjectsCingulate gyrusCortical areasReflexive saccadesPatientsAbnormal activationControl group