2023
The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2021
Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis
Zhornitsky S, Chaudhary S, Le TM, Chen Y, Zhang S, Potvin S, Chao HH, van Dyck CH, Li CR. Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis. Psychiatry Research Neuroimaging 2021, 317: 111380. PMID: 34482052, PMCID: PMC8579376, DOI: 10.1016/j.pscychresns.2021.111380.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlzheimer's diseaseHippocampal formationUse disordersHigher Clinical Dementia Rating Scale-SumVentricular volumeVolumetric deficitsCingulate cortexClinical Dementia Rating Scale SumCoordinating CenterSmaller hippocampal volumesLarger ventricular volumesNational Alzheimer's Coordinating CenterIsthmus cingulate cortexPosterior cingulate cortexMisuse of alcoholSuperior parietal cortexDistinct brain regionsCognitive dysfunctionHippocampal volumeInferior frontal gyrusRegional GMVHigh riskDementia severityDual diagnosis