Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases
Yogev S, Schejter ED, Shilo B. Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases. The EMBO Journal 2008, 27: 1219-1230. PMID: 18369317, PMCID: PMC2367402, DOI: 10.1038/emboj.2008.58.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CompartmentationCell LineDrosophila melanogasterDrosophila ProteinsEndoplasmic ReticulumEpidermal Growth FactorErbB ReceptorsEye ProteinsGerm CellsHydrolysisIntracellular MembranesMembrane ProteinsProtein KinasesReceptors, Invertebrate PeptideRho GTP-Binding ProteinsSerine EndopeptidasesSignal TransductionConceptsLate compartmentsRho proteinsDifferential compartmentalizationEGFR activationRhomboid intramembrane proteasesEGF receptor activationAmount of chaperoneEGF receptor ligandsIntramembrane proteasesDrosophila EGFRSecretory pathwayGerm lineCompartment localizationSubsequent secretionProteinCompartmentalizationReceptor activationRho 3CompartmentsActivationChaperonesERProteasePathwayReceptor ligands