2023
AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells
Wu J, Gulati S, Teague A, Kim Y, Tryggestad J, Jiang S. AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells. Stem Cells And Development 2023, 32: 131-139. PMID: 36594575, PMCID: PMC9986020, DOI: 10.1089/scd.2022.0226.Peer-Reviewed Original ResearchConceptsActivation of AMP-activated protein kinasePGC-1a expressionMitochondrial programDNA methylationCompound CMitochondrial biogenesisAMPK activationActivation of AMPKAMP-activated protein kinaseAMPK inhibitor compound CInhibition of DNA methylationRegulator of mitochondrial biogenesisRegulate mitochondrial biogenesisPGC-1aInhibitor compound CPromoter methylationIncreased mitochondrial functionRegulation of energy metabolismMitochondrial DNAEpigenetic landscapeDNA demethylationMtDNA abundanceMyogenic differentiationEpigenetic regulationProtein kinase
2020
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Jiang S, Teague A, Tryggestad J, Lyons T, Chernausek S. Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Molecular Medicine 2020, 26: 76. PMID: 32762639, PMCID: PMC7409642, DOI: 10.1186/s10020-020-00205-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAdultBiomarkersBlood GlucoseCase-Control StudiesDiabetes, GestationalDNA, MitochondrialFemaleFetal BloodHumansLeukocytes, MononuclearMaternal ExposureMesenchymal Stem CellsMitochondriaOrganelle BiogenesisPlacentaPregnancyPrenatal Exposure Delayed EffectsResistinStress, PhysiologicalTrophoblastsConceptsCord blood mononuclear cellsBlood mononuclear cellsSecretion of resistinHuman resistinMononuclear cellsBeWo cellsCultured cord blood mononuclear cellsMeasures of maternal glycemiaMesenchymal stem cellsLong-term health of offspringExposed BeWo cellsImpact fetal developmentPlacental mitochondrial contentCirculation of infantsPlacental trophoblast cellsHuman placental explantsAdipocyte-derived factorsHealth of offspringMaternal glycemiaResponse to high glucoseDiabetic pregnanciesFetal circulationMaternal diabetesCord bloodCord sera