2020
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Jiang S, Teague A, Tryggestad J, Lyons T, Chernausek S. Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Molecular Medicine 2020, 26: 76. PMID: 32762639, PMCID: PMC7409642, DOI: 10.1186/s10020-020-00205-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAdultBiomarkersBlood GlucoseCase-Control StudiesDiabetes, GestationalDNA, MitochondrialFemaleFetal BloodHumansLeukocytes, MononuclearMaternal ExposureMesenchymal Stem CellsMitochondriaOrganelle BiogenesisPlacentaPregnancyPrenatal Exposure Delayed EffectsResistinStress, PhysiologicalTrophoblastsConceptsCord blood mononuclear cellsBlood mononuclear cellsSecretion of resistinHuman resistinMononuclear cellsBeWo cellsCultured cord blood mononuclear cellsMeasures of maternal glycemiaMesenchymal stem cellsLong-term health of offspringExposed BeWo cellsImpact fetal developmentPlacental mitochondrial contentCirculation of infantsPlacental trophoblast cellsHuman placental explantsAdipocyte-derived factorsHealth of offspringMaternal glycemiaResponse to high glucoseDiabetic pregnanciesFetal circulationMaternal diabetesCord bloodCord sera
2019
Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma
Tryggestad J, Teague A, Sparling D, Jiang S, Chernausek S. Macrophage‐Derived microRNA‐155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator‐Activated Receptor Gamma. Obesity 2019, 27: 1856-1864. PMID: 31531958, PMCID: PMC6832842, DOI: 10.1002/oby.22616.Peer-Reviewed Original ResearchConceptsAdipose tissue macrophagesMiR-155Mesenchymal stem cellsStem cellsPeripheral blood mononuclear cellsPeroxisome proliferator-activated receptor gammaBlood mononuclear cellsImpact of obesityProliferator-activated receptor gammaInfluence adipocyte metabolismMiR-130b expressionCell type-specific fashionIncreased 1.8-foldType-specific fashionPPARG mRNA expressionWestern blot analysisMononuclear cellsPolymerase chain reactionQuantitative polymerase chain reactionMiRNA expressionHuman mesenchymal stem cellsTissue macrophagesDifferentiated 3T3-L1 adipocytesMRNA expressionObesity