2007
Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa
Bailer U, Frank G, Henry S, Price J, Meltzer C, Mathis C, Wagner A, Thornton L, Hoge J, Ziolko S, Becker C, McConaha C, Kaye W. Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa. Biological Psychiatry 2007, 61: 1090-1099. PMID: 17241616, DOI: 10.1016/j.biopsych.2006.07.018.Peer-Reviewed Original ResearchConceptsPositron emission tomographyILL ANCerebral blood flowControl womenAnorexia nervosaBlood flowReceptor activityOrbital frontal regionsDorsal raphe nucleusHealthy control womenLateral temporal lobeReceptor-specific radioligandReceptor BPRaphe nucleusPoor responseSerotonin activityTemporal lobeParietal cortexEmission tomographyReceptor functionParietal regionsWomenReceptorsFrontal regionsSignificant increase
2005
Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635
Bailer U, Frank G, Henry S, Price J, Meltzer C, Weissfeld L, Mathis C, Drevets W, Wagner A, Hoge J, Ziolko S, McConaha C, Kaye W. Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635. JAMA Psychiatry 2005, 62: 1032-1041. PMID: 16143735, DOI: 10.1001/archpsyc.62.9.1032.Peer-Reviewed Original ResearchConceptsRestricting-type anorexia nervosaPositron emission tomographyAnorexia nervosaReceptor bindingEmission tomographyControl womenPathogenesis of ANDistribution volumeHealthy control womenEffects of malnutritionSerotonin neuronal activityLogan graphical methodPrefrontal cortical regionsSubgenual cingulate regionsBrain serotoninDorsal rapheReceptor antagonistSerotonergic functionBody of evidenceNeuronal activityCingulate regionsReceptor activityCortical regionsMeasures of anxietyWomen