Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa
Bailer U, Frank G, Henry S, Price J, Meltzer C, Mathis C, Wagner A, Thornton L, Hoge J, Ziolko S, Becker C, McConaha C, Kaye W. Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa. Biological Psychiatry 2007, 61: 1090-1099. PMID: 17241616, DOI: 10.1016/j.biopsych.2006.07.018.Peer-Reviewed Original ResearchConceptsPositron emission tomographyILL ANCerebral blood flowControl womenAnorexia nervosaBlood flowReceptor activityOrbital frontal regionsDorsal raphe nucleusHealthy control womenLateral temporal lobeReceptor-specific radioligandReceptor BPRaphe nucleusPoor responseSerotonin activityTemporal lobeParietal cortexEmission tomographyReceptor functionParietal regionsWomenReceptorsFrontal regionsSignificant increase