2012
Identification of Intermediate in Evolutionary Model of Enterohemorrhagic Escherichia coli O157 - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC
Jenke C, Leopold S, Weniger T, Rothgänger J, Harmsen D, Karch H, Mellmann A. Identification of Intermediate in Evolutionary Model of Enterohemorrhagic Escherichia coli O157 - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 582-588. PMID: 22469031, PMCID: PMC3309690, DOI: 10.3201/eid1804.111414.Peer-Reviewed Original ResearchConceptsH7/HEHEC O157Partial open reading frameEvolutionary modelsOpen reading frameStepwise evolutionary modelSingle nucleotide polymorphism analysisEnterohemorrhagic Escherichia coli O157Nucleotide polymorphism analysisGenomic regionsSingle nucleotide polymorphismsReading frameHuman pathogensNucleotide polymorphismsCurrent evolutionary modelsNonhuman reservoirsPolymorphism analysisEscherichia coli O157Animal originHypothetical intermediateH isolatesColi O157O157Intermediate positionIntermediates
2009
A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis
Leopold S, Magrini V, Holt N, Shaikh N, Mardis E, Cagno J, Ogura Y, Iguchi A, Hayashi T, Mellmann A, Karch H, Besser T, Sawyer S, Whittam T, Tarr P. A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 8713-8718. PMID: 19439656, PMCID: PMC2689004, DOI: 10.1073/pnas.0812949106.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsEffective population sizeSynonymous single nucleotide polymorphismsClusters of organismsGene clusterSpecies evolutionGenome regionsEvolutionary dynamicsPathogenic Escherichia coli O157Selective advantageEscherichia coli O157Related pathogensPopulation sizeNucleotide polymorphismsTenuous survivalPathogenic O157Coli O157OrganismsFalse associationsPathogensORFH7Backbone regionO157Mutations