2013
Phylogeny and phenotypes of clinical and environmental Shiga toxin‐producing Escherichia coli O174
Zhang W, Nadirk J, Kossow A, Bielaszewska M, Leopold S, Witten A, Fruth A, Karch H, Ammon A, Mellmann A. Phylogeny and phenotypes of clinical and environmental Shiga toxin‐producing Escherichia coli O174. Environmental Microbiology 2013, 16: 963-976. PMID: 24034719, DOI: 10.1111/1462-2920.12234.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsBacterial AdhesionCattleCell LineChlorocebus aethiopsDrug Resistance, Multiple, BacterialEscherichia coli ProteinsGenotypeHumansIntestinal MucosaMolecular Sequence DataMultilocus Sequence TypingPhenotypePhylogenyShiga ToxinShiga-Toxigenic Escherichia coliVero CellsConceptsDifferent clinical outcomesHaemolytic uremic syndromeMultilocus sequence typingClinical outcomesUremic syndromeStx genotypesH antigensShiga toxinO174Animal reservoirsSequence typingIntimin geneDifferent serotypesVirulence factorsAdherence capacitySerotypesNegative STECSTECSequence typesPhenotypic heterogeneityNon-motile isolatesToxinIsolate originVirulence lociDifferent genotypes
2011
Intestinal damage in enterohemorrhagic Escherichia coli infection
Békássy Z, Calderon Toledo C, Leoj G, Kristoffersson A, Leopold S, Perez M, Karpman D. Intestinal damage in enterohemorrhagic Escherichia coli infection. Pediatric Nephrology 2011, 26: 2059-2071. PMID: 20809220, DOI: 10.1007/s00467-010-1616-9.Peer-Reviewed Original ResearchConceptsEnterohemorrhagic Escherichia coli infectionEscherichia coli infectionTUNEL-positive cellsIntestinal injuryIntestinal damageColi infectionSevere symptomsType III secretion effectorsAbundant TUNEL-positive cellsC3H/HeN micePresence of Stx2Mucosal cell deathMore TUNEL-positive cellsShiga toxin 2Fecal bacterial countsBacterial virulence factorsPresence of intiminSigmoid colonHeN miceDistal colonEHEC infectionMore symptomsToxin 2Strain 87Symptoms
2010
Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7
Leopold S, Shaikh N, Tarr P. Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7. Infection Genetics And Evolution 2010, 10: 1282-1285. PMID: 20691811, PMCID: PMC3742067, DOI: 10.1016/j.meegid.2010.07.021.Peer-Reviewed Original ResearchMeSH KeywordsBacterial Typing TechniquesBase SequenceBiological EvolutionDNA, BacterialEscherichia coliEscherichia coli O157Escherichia coli ProteinsEvolution, MolecularGene ExpressionGenetic VariationGenome, BacterialGenomicsGenotypeHumansMutationO AntigensPolymerase Chain ReactionPolymorphism, Single NucleotideRecombination, GeneticSequence Analysis, DNAShiga ToxinsVirulence