2018
Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors
Tao J, Bukanova EN, Akhtar S. Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors. Journal Of Intensive Care 2018, 6: 34. PMID: 29942519, PMCID: PMC6001072, DOI: 10.1186/s40560-018-0303-y.Peer-Reviewed Original ResearchSequential compression devicesFactor Xa inhibitorsThrombotic eventsProthrombin complex concentrateXa inhibitorsMajor bleedingEmergent reversalComplex concentrateInvasive proceduresIU/Single-center retrospective reviewChronic oral anticoagulationEmergent decompressive craniotomyRate of thromboembolismResultsForty-three patientsUpper extremity DVTMulticenter prospective trialDeep vein thrombosisTreatment of choiceCerebral vascular accidentMinor invasive proceduresTraumatic intracranial hemorrhageRisk of thrombosisEmergent invasive proceduresDVT prophylaxis
1999
INTRAOPERATIVE USE OF ANTICOAGULANTS AND ANTITHROMBOTICS Heparin and Beyond
Akhtar S, Brull S. INTRAOPERATIVE USE OF ANTICOAGULANTS AND ANTITHROMBOTICS Heparin and Beyond. Anesthesiology Clinics 1999, 17: 831-860. DOI: 10.1016/s0889-8537(05)70136-x.ChaptersDeep vein thrombosisThrombus formationUnfractionated heparinSurgical interventionHemostatic systemIntraoperative useFatal pulmonary embolismVascular reconstructive proceduresCertain surgical interventionsArterial thrombus formationCardiopulmonary bypass proceduresLess side effectsNew anticoagulant agentsCertain surgical proceduresWide clinical useSubepithelial surfaceAntithrombotic therapyPulmonary embolismVein thrombosisAnesthetic implicationsIntraoperative anticoagulationAnesthetic techniqueBypass proceduresPerioperative monitoringClinical management