2008
Preoperative β-blocker use: impact of national guidelines on clinical practice
Akhtar S, Assaad, Amin M, Holt NF, Barash PG, Silverman DG. Preoperative β-blocker use: impact of national guidelines on clinical practice. Journal Of Clinical Anesthesia 2008, 20: 122-128. PMID: 18410867, DOI: 10.1016/j.jclinane.2007.09.012.Peer-Reviewed Original ResearchConceptsBeta-blocker groupPost-guideline patientsPre-guideline groupVascular surgery patientsCoronary artery bypassTarget HRArtery bypassSurgery patientsPerioperative beta-blocker therapyPreoperative beta-blocker useTertiary care teaching hospitalMean HRElective vascular surgeryPost-guideline groupVascular surgery groupBeta-blocker therapyBeta-blocker useUnpaired t-testEligible patientsSurgery groupPreanesthetic evaluationVascular surgeryPresurgical patientsTeaching hospitalObservational study
2006
Heparin Displaces Interferon-γ–Inducible Chemokines (IP-10, I-TAC, and Mig) Sequestered in the Vasculature and Inhibits the Transendothelial Migration and Arterial Recruitment of T Cells
Ranjbaran H, Wang Y, Manes TD, Yakimov AO, Akhtar S, Kluger MS, Pober JS, Tellides G. Heparin Displaces Interferon-γ–Inducible Chemokines (IP-10, I-TAC, and Mig) Sequestered in the Vasculature and Inhibits the Transendothelial Migration and Arterial Recruitment of T Cells. Circulation 2006, 114: 1293-1300. PMID: 16940188, DOI: 10.1161/circulationaha.106.631457.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory AgentsCell MovementCells, CulturedChemokine CXCL10Chemokine CXCL11Chemokine CXCL9ChemokinesChemokines, CXCCoronary Artery DiseaseCoronary VesselsEndothelium, VascularHeparinHeparin AntagonistsHumansInterferon-gammaInterleukin-12ProtaminesProtein BindingReceptors, ChemokineReceptors, CXCR3T-LymphocytesTh1 CellsConceptsIP-10Heparin administrationCoronary arteryEndothelial cellsI-TACT cellsIFN-gamma-dependent productionTh1-type inflammatory diseasesI-TAC/CXCL11IP-10/CXCL10IFN-gamma-producing Th1 cellsTransendothelial migrationInflammatory arterial diseaseNonanticoagulant heparin derivativesCoronary artery bypassChemokines IP-10/CXCL10Memory T cellsT helper cellsMIG/CXCL9IFN-gamma responsesEffect of heparinAtherosclerotic coronary arteriesHuman coronary arteriesImmunodeficient mouse hostsCultured endothelial cells