2003
Glucocorticoid Enhances Transforming Growth Factor-β Effects on Extracellular Matrix Protein Expression in Human Placental Mesenchymal Cells1
Lee MJ, Ma Y, LaChapelle L, Kadner SS, Guller S. Glucocorticoid Enhances Transforming Growth Factor-β Effects on Extracellular Matrix Protein Expression in Human Placental Mesenchymal Cells1. Biology Of Reproduction 2003, 70: 1246-1252. PMID: 14681196, DOI: 10.1095/biolreprod.103.021956.Peer-Reviewed Original ResearchConceptsPlacental mesenchymal cellsIntrauterine growth restrictionFFN levelsProtein expressionCol IV expressionInteraction of glucocorticoidsDose-dependent mannerHuman term placentaFibronectin protein levelsExtracellular matrix protein expressionUncomplicated pregnanciesPolymerase chain reaction analysisReal-time polymerase chain reaction analysisGrowth restrictionDEX treatmentChain reaction analysisECM proteinsPlacental villiTerm placentaECM protein expressionCol IIIPlacental architectureMatrix protein expressionDexamethasoneGlucocorticoids
2002
Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β
Ma Y, Ryu JS, Dulay A, Segal M, Guller S. Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β. Placenta 2002, 23: 727-734. PMID: 12398812, DOI: 10.1053/plac.2002.0863.Peer-Reviewed Original ResearchConceptsHTR-8/SVneo cellsIntrauterine growth restrictionPAI-2 levelsPAI-1 expressionPlasminogen activator inhibitorActivator inhibitorGrowth factorHuman trophoblast cell linePAI-1 levelsTrophoblast cell lineTransforming Growth FactorTGF-beta treatmentTGF-beta effectsPAI-1 proteinFibrin depositionGrowth restrictionDEX treatmentSynthetic glucocorticoidGlucocorticoidsPAI-1Regulation of fibrinolysisDexamethasoneTGF betaExcessive productionMRNA expression
1998
Apoptosis and Fas Expression in Human Fetal Membranes1
Runić R, Lockwood C, LaChapelle L, Dipasquale B, Demopoulos R, Kumar A, Guller S. Apoptosis and Fas Expression in Human Fetal Membranes1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 660-666. PMID: 9467589, DOI: 10.1210/jcem.83.2.4600.Peer-Reviewed Original ResearchConceptsChorionic trophoblastsHuman fetal membranesFetal membranesApoptotic indexWeeks groupCell layerHuman fetal membrane cellsCytoplasmic domain of FasFetal membrane cellsFas messenger ribonucleic acidTrophoblast cell layerDecidual cell typesCondensation of chromatinConsistent with apoptosisSamples of amnionEpithelial cell layerMessenger ribonucleic acidCell surface receptorsWeeks gestationDecidual cellsProstate glandAmnion epitheliumFas signalingAmniotic tissueImmunohistochemical staining