2019
IL‐10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses
Kaislasuo J, Simpson S, Petersen JF, Peng G, Aldo P, Lokkegaard E, Paidas M, Pal L, Guller S, Mor G. IL‐10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses. American Journal Of Reproductive Immunology 2019, 83: e13195. PMID: 31585488, PMCID: PMC8295882, DOI: 10.1111/aji.13195.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultCohort StudiesFemaleFertilization in VitroHumansInterleukin-10PregnancyPregnancy Trimester, FirstTumor Necrosis Factor-alphaConceptsWeeks of gestationIL-10Pregnancy lossHealthy pregnancyFirst trimesterTNFα ratioNormal pregnancySymptoms of miscarriageIL-10 concentrationsProspective longitudinal cohortEarly first trimesterFirst trimester lossImplantation dayIVF cohortImmunological balanceSerum levelsViable pregnancySerial bloodGestation weeksTNFα concentrationsEarly immunomodulationLongitudinal cohortEmbryo implantationPregnancySingle time pointThermal stability of cytokines: A review
Simpson S, Kaislasuo J, Guller S, Pal L. Thermal stability of cytokines: A review. Cytokine 2019, 125: 154829. PMID: 31472404, DOI: 10.1016/j.cyto.2019.154829.Peer-Reviewed Original Research
2016
Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE)
Shaw J, Tang Z, Schneider H, Saljé K, Hansson SR, Guller S. Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE). Placenta 2016, 43: 1-8. PMID: 27324092, DOI: 10.1016/j.placenta.2016.04.015.Peer-Reviewed Original ResearchConceptsPro-inflammatory cytokine secretionMaternal perfusateCytokine secretionEndothelial dysfunctionActivation markersEndothelial cellsTNF-α blocking antibodyDual perfusion modelMaternal endothelial dysfunctionPro-inflammatory cytokinesMCP-1 secretionTNF-α actionEndothelial cell linePlacental pathophysiologyEndothelial activationIL-6IL-8Maternal endotheliumInflammatory processDual perfusionMaternal circulationBlocking antibodiesPreeclampsiaTNFPerfusion model
2006
Tumor Necrosis Factor-α and Interleukin-1β Regulate Interleukin-8 Expression in Third Trimester Decidual Cells Implications for the Genesis of Chorioamnionitis
Lockwood CJ, Arcuri F, Toti P, De Felice C, Krikun G, Guller S, Buchwalder LF, Schatz F. Tumor Necrosis Factor-α and Interleukin-1β Regulate Interleukin-8 Expression in Third Trimester Decidual Cells Implications for the Genesis of Chorioamnionitis. American Journal Of Pathology 2006, 169: 1294-1302. PMID: 17003486, PMCID: PMC1698845, DOI: 10.2353/ajpath.2006.060185.Peer-Reviewed Original ResearchConceptsTerm decidual cellsIL-8 expressionInterleukin-8 expressionTranscriptase-polymerase chain reactionDecidual cellsNeutrophil infiltrationIL-8TNF-alphaIL-8 secretion levelsIL-8 levelsIntense neutrophil infiltrationReverse transcriptase-polymerase chain reactionChain reactionInterleukin-1 betaTumor necrosis factorIL-8 mRNAEnzyme-linked immunosorbentIL-8 outputConcentration-response studiesNeutrophil infiltrateSteroidal milieuTerm deciduaTumor necrosisNecrosis factorImmunohistochemical staining