2014
Trophoblast Induces Monocyte Differentiation Into CD14+/CD16+ Macrophages
Aldo PB, Racicot K, Craviero V, Guller S, Romero R, Mor G. Trophoblast Induces Monocyte Differentiation Into CD14+/CD16+ Macrophages. American Journal Of Reproductive Immunology 2014, 72: 270-284. PMID: 24995492, PMCID: PMC4230492, DOI: 10.1111/aji.12288.Peer-Reviewed Original ResearchConceptsUnique macrophage phenotypeMacrophage phenotypeMonocyte differentiationFirst trimester trophoblast cellsPeripheral blood monocytesPhenotype of macrophagesCD14 surface expressionNormal deciduaHealthy pregnancyIL-10Chemokine productionEarly pregnancyIP-10Monocyte exposureIL-1BBlood monocytesDecidual phenotypePhagocytic capacityTrophoblast cellsFlow cytometryMorphologic changesMacrophagesMonocytesSurface expressionPlacenta development
1999
Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1
Ryu J, Majeska R, Ma Y, LaChapelle L, Guller S. Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1. Endocrinology 1999, 140: 3904-3908. DOI: 10.1210/en.140.9.3904.Peer-Reviewed Original ResearchExtracellular matrix ligandsHuman cytotrophoblastsControl levelsMessenger RNATreatment of cytotrophoblastsMRNA levelsIntegrin subunitsCell surface expressionHuman term placentaExtracellular matrixDays of treatmentHuman pregnancyExpression of collagenHeterodimeric transmembrane glycoproteinsTerm placentaCytotrophoblastDexamethasone effectDown-regulated expressionHuman placentaSurface expressionCellular adhesion receptorsDexamethasoneGC treatmentGlucocorticoidIntegrin levels