2011
Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression
Wu XX, Guller S, Rand JH. Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression. American Journal Of Obstetrics And Gynecology 2011, 205: 576.e7-576.e14. PMID: 21871597, PMCID: PMC3224185, DOI: 10.1016/j.ajog.2011.06.064.Peer-Reviewed Original ResearchConceptsAntiphospholipid antibodiesHuman placental syncytiotrophoblastPlacental syncytiotrophoblastAnnexin A5 anticoagulant shieldA5 expressionEffect of hydroxychloroquineAnnexin A5 expressionFirst morphologic evidenceAntibody-mediated disruptionAntiphospholipid syndromeComputer-based morphometric analysisThrombogenic mechanismsBeWo trophoblastsImmune complexesNovel treatmentsHydroxychloroquineAntimalarial drugsImmunoglobulin G (IgG) bindingMorphologic evidenceSyncytiotrophoblastImmunoglobulin GsPrimary culturesAntibodiesAnnexin A5Laser confocal microscopy
2005
Alterations in Syncytiotrophoblast Cytokine Expression Following Treatment with Lipopolysaccharide
Ma Y, Mor G, Abrahams VM, Buhimschi IA, Buhimschi CS, Guller S. Alterations in Syncytiotrophoblast Cytokine Expression Following Treatment with Lipopolysaccharide. American Journal Of Reproductive Immunology 2005, 55: 12-18. PMID: 16364007, DOI: 10.1111/j.1600-0897.2005.00347.x.Peer-Reviewed Original ResearchConceptsCytokine expressionLPS treatmentInflammatory compoundsAnti-inflammatory cytokinesIL-8 levelsInterleukin-8 levelsAnti-inflammatory compoundsEnzyme-linked immunosorbent assayCell typesCytokine levelsGlucocorticoid treatmentMaternal bloodDEX treatmentPlacental syncytiumSyncytiotrophoblastImmunosorbent assayLPSPrimary culturesTreatmentCytokinesFourfold increaseExpressionSyncytiaGestationLevels