2019
IL‐10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses
Kaislasuo J, Simpson S, Petersen JF, Peng G, Aldo P, Lokkegaard E, Paidas M, Pal L, Guller S, Mor G. IL‐10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses. American Journal Of Reproductive Immunology 2019, 83: e13195. PMID: 31585488, PMCID: PMC8295882, DOI: 10.1111/aji.13195.Peer-Reviewed Original ResearchConceptsWeeks of gestationIL-10Pregnancy lossHealthy pregnancyFirst trimesterTNFα ratioNormal pregnancySymptoms of miscarriageIL-10 concentrationsProspective longitudinal cohortEarly first trimesterFirst trimester lossImplantation dayIVF cohortImmunological balanceSerum levelsViable pregnancySerial bloodGestation weeksTNFα concentrationsEarly immunomodulationLongitudinal cohortEmbryo implantationPregnancySingle time point
2010
Protein composition of microparticles shed from human placenta during placental perfusion: Potential role in angiogenesis and fibrinolysis in preeclampsia
Guller S, Tang Z, Ma YY, Di Santo S, Sager R, Schneider H. Protein composition of microparticles shed from human placenta during placental perfusion: Potential role in angiogenesis and fibrinolysis in preeclampsia. Placenta 2010, 32: 63-69. PMID: 21074265, PMCID: PMC3762591, DOI: 10.1016/j.placenta.2010.10.011.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitorMaternal perfusateSFlt-1Maternal endothelial cell dysfunctionFms-like tyrosine kinasePathophysiology of preeclampsiaMaternal-fetal interfaceEndothelial cell dysfunctionAnti-angiogenic actionFollowing relative levelsPlacental damagePlacental perfusionMaternal serumNormal pregnancyPlacental pathophysiologyAnnexin V bindingSyncytiotrophoblast microparticlesDual perfusionAngiogenic balanceCell dysfunctionMaternal bloodPreeclampsiaActivator inhibitorCytometric analysisLevel of expression
2005
A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells
Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R, Mor G. A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells. The Journal Of Immunology 2005, 175: 8096-8104. PMID: 16339547, DOI: 10.4049/jimmunol.175.12.8096.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsInnate immune cellsMaternal-fetal interfaceTrophoblast cellsIntrauterine infectionPregnancy complicationsNormal pregnancyImmune cellsImmune responseImmune systemHuman first trimester trophoblast cellsGrowth-related oncogene alphaCertain pregnancy complicationsElevated leukocyte infiltrationMaternal immune systemGrowth-related oncogeneTLR-3 stimulationImmune cell migrationSecretion of chemokinesInnate immune systemElevated monocytesPaternal AgsPreterm laborNK cellsTLR-3
2004
First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis
Abrahams VM, Straszewski-Chavez S, Guller S, Mor G. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Molecular Human Reproduction 2004, 10: 55-63. PMID: 14665707, DOI: 10.1093/molehr/gah006.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsImmune privilegeTrophoblast cellsFas/Fas ligand (FasL) apoptotic pathwayMaternal immune recognitionMaternal immune systemImmune cell apoptosisSecretion of FasLT cell deathPaternal alloantigensAllograft rejectionNormal pregnancyPeripheral toleranceImmune recognitionImmune systemRelease of microvesiclesFas ligandCell apoptosisVivo studiesFasLMembrane-associated expressionTrophoblastIntracellular FasLApoptotic pathwayDeath