2014
Toll‐like Receptor‐Mediated Responses by Placental Hofbauer Cells (HBCs): A Potential Pro‐Inflammatory Role for Fetal M2 Macrophages
Young OM, Tang Z, Niven‐Fairchild T, Tadesse S, Krikun G, Norwitz ER, Mor G, Abrahams VM, Guller S. Toll‐like Receptor‐Mediated Responses by Placental Hofbauer Cells (HBCs): A Potential Pro‐Inflammatory Role for Fetal M2 Macrophages. American Journal Of Reproductive Immunology 2014, 73: 22-35. PMID: 25345551, PMCID: PMC4268350, DOI: 10.1111/aji.12336.Peer-Reviewed Original ResearchConceptsHofbauer cellsHuman umbilical vein endothelial cellsM2 macrophagesTLR-3TLR-4Potential pro-inflammatory roleToll-like receptor functionPlacental villous coreAdverse pregnancy outcomesPro-inflammatory rolePlacental Hofbauer cellsIL-6 secretionToll-like receptorsPolycytidylic acid treatmentUmbilical vein endothelial cellsFetal inflammationPregnancy outcomesVein endothelial cellsTLR agonistsTLR-2Cytokine secretionInflammatory responseVillous corePlacental fibroblastsReceptor function
2012
Glucocorticoids Enhance CD163 Expression in Placental Hofbauer Cells
Tang Z, Niven-Fairchild T, Tadesse S, Norwitz ER, Buhimschi CS, Buhimschi IA, Guller S. Glucocorticoids Enhance CD163 Expression in Placental Hofbauer Cells. Endocrinology 2012, 154: 471-482. PMID: 23142809, PMCID: PMC3529384, DOI: 10.1210/en.2012-1575.Peer-Reviewed Original ResearchConceptsHofbauer cellsGC treatmentGC administrationCD163 expressionDEX treatmentCD68 mRNASpontaneous preterm birthMacrophage marker genesPlacental explant culturesAntiinflammatory M2 macrophagesHuman term placentaExpression of FRPreterm deliveryPreterm birthCD163 mRNAM2 macrophagesReceptor mRNAGC actionSynthetic GCFetal capillariesTerm placentaPlacental fibroblastsFlow cytometryCD163 proteinFetal macrophages