2012
Glucocorticoids Enhance CD163 Expression in Placental Hofbauer Cells
Tang Z, Niven-Fairchild T, Tadesse S, Norwitz ER, Buhimschi CS, Buhimschi IA, Guller S. Glucocorticoids Enhance CD163 Expression in Placental Hofbauer Cells. Endocrinology 2012, 154: 471-482. PMID: 23142809, PMCID: PMC3529384, DOI: 10.1210/en.2012-1575.Peer-Reviewed Original ResearchConceptsHofbauer cellsGC treatmentGC administrationCD163 expressionDEX treatmentCD68 mRNASpontaneous preterm birthMacrophage marker genesPlacental explant culturesAntiinflammatory M2 macrophagesHuman term placentaExpression of FRPreterm deliveryPreterm birthCD163 mRNAM2 macrophagesReceptor mRNAGC actionSynthetic GCFetal capillariesTerm placentaPlacental fibroblastsFlow cytometryCD163 proteinFetal macrophages
2005
Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts
Lee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ, Guller S. Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts. Endocrinology 2005, 146: 4619-4626. PMID: 16055431, DOI: 10.1210/en.2005-0235.Peer-Reviewed Original ResearchConceptsGC receptorSmooth muscle cellsHuman placentaGR levelsHormone treatmentShort-term GC treatmentMuscle cellsLong-term hormone treatmentVascular smooth muscle cellsGR protein expressionGR mRNA levelsPlacental cell typesNormal term human placentasTotal GR levelsTerm human placentaCell typesGR antibodyGC treatmentHormone exposureStem villiCytotrophoblast cellsGlucocorticoid receptorPlacental fibroblastsTerminal villiVillous fibroblasts
1999
Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1
Ryu J, Majeska R, Ma Y, LaChapelle L, Guller S. Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1. Endocrinology 1999, 140: 3904-3908. DOI: 10.1210/en.140.9.3904.Peer-Reviewed Original ResearchExtracellular matrix ligandsHuman cytotrophoblastsControl levelsMessenger RNATreatment of cytotrophoblastsMRNA levelsIntegrin subunitsCell surface expressionHuman term placentaExtracellular matrixDays of treatmentHuman pregnancyExpression of collagenHeterodimeric transmembrane glycoproteinsTerm placentaCytotrophoblastDexamethasone effectDown-regulated expressionHuman placentaSurface expressionCellular adhesion receptorsDexamethasoneGC treatmentGlucocorticoidIntegrin levels