2002
Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp
Travi BL, Osorio Y, Melby PC, Chandrasekar B, Arteaga L, Saravia NG. Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp. Infection And Immunity 2002, 70: 2288-2296. PMID: 11953362, PMCID: PMC127932, DOI: 10.1128/iai.70.5.2288-2296.2002.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAntibodies, ProtozoanCricetinaeCytokinesFemaleGonadal Steroid HormonesHypersensitivity, DelayedLeishmaniasisMaleMesocricetusRNA, MessengerSex FactorsConceptsFemale animalsGender-related differencesMale animalsImmune responseInterleukin-4Lesion sizeDistant cutaneous sitesPermissive immune responsePrepubertal male animalsSevere cutaneous lesionsSex hormone statusLeishmania sppTGF-beta mRNASeverity of diseaseAdult male animalsGreater lesion sizeGrowth factor betaGreater parasite burdenIntralesional expressionCutaneous sitesIL-10Lymph nodesChronic lesionsClinical evolutionCutaneous infections
2000
Distinct Innate and Acquired Immune Responses to Leishmania in Putative Susceptible and Resistant Human Populations Endemically Exposed to L. (Viannia) panamensis Infection
Bosque, Saravia, Valderrama, Milon. Distinct Innate and Acquired Immune Responses to Leishmania in Putative Susceptible and Resistant Human Populations Endemically Exposed to L. (Viannia) panamensis Infection. Scandinavian Journal Of Immunology 2000, 51: 533-541. PMID: 10792848, DOI: 10.1046/j.1365-3083.2000.00724.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedDisease SusceptibilityEndemic DiseasesFemaleHumansHypersensitivity, DelayedImmunity, InnateInterferon-gammaInterleukin-10Leishmania guyanensisLeishmaniasis, MucocutaneousMacrophagesMaleMiddle AgedMonocytesRecombinant ProteinsRecurrenceRisk FactorsTritiumTumor Necrosis Factor-alphaConceptsPeripheral blood mononuclear cellsRecurrent diseaseL. panamensis infectionsCD8 T lymphocytesType hypersensitivity responseBlood mononuclear cellsAcquired Immune ResponsesTumor necrosis factorProduction of interferonEntry of parasitesLeishmania Viannia panamensisPanamensis infectionRecurrent leishmaniasisHypersensitivity responseImmunological basisSkin testMononuclear cellsNecrosis factorT lymphocytesImmune responseSubclinical infectionLinear regression analysisEvidence of differencesDistinct innateIntracellular amastigotes
1996
The inflammatory response promotes cutaneous metastasis in hamsters infected with Leishmania (Viannia) panamensis.
Travi B, Osorio Y, Saravia N. The inflammatory response promotes cutaneous metastasis in hamsters infected with Leishmania (Viannia) panamensis. Journal Of Parasitology 1996, 82: 454-7. PMID: 8636852, DOI: 10.2307/3284085.Peer-Reviewed Original ResearchConceptsInflammatory responseMetastatic lesionsControl animalsL. panamensisLeishmania panamensis infectionType hypersensitivity responseFrequency of metastasisNonspecific inflammatory responseDevelopment of lesionsExperimental groupElicitation of inflammationPanamensis infectionSkin metastasesCutaneous metastasesHind pawsSurgical excisionHypersensitivity responseSite of inductionIntradermal applicationSecondary diseaseHamster modelInflammatory stimuliLeishmania panamensisMetastasisLesions
1991
Leishmanin skin test standardization and evaluation of safety, dose, storage, longevity of reaction and sensitization.
Weigle K, Valderrama L, Arias A, Santrich C, Saravia N. Leishmanin skin test standardization and evaluation of safety, dose, storage, longevity of reaction and sensitization. American Journal Of Tropical Medicine And Hygiene 1991, 44: 260-71. PMID: 2035747, DOI: 10.4269/ajtmh.1991.44.260.Peer-Reviewed Original Research
1989
The Relationship of Leishmania braziliensis Subspecies and Immune Response to Disease Expression in New World Leishmaniasis
Saravia N, Valderrama L, Labrada M, Holguin A, Navas C, Palma G, Weigle K. The Relationship of Leishmania braziliensis Subspecies and Immune Response to Disease Expression in New World Leishmaniasis. The Journal Of Infectious Diseases 1989, 159: 725-735. PMID: 2647862, DOI: 10.1093/infdis/159.4.725.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodies, ProtozoanAntigens, ProtozoanDose-Response Relationship, ImmunologicFluorescent Antibody TechniqueHost-Parasite InteractionsHumansHypersensitivity, DelayedImmune SeraImmunity, CellularKineticsLeishmaniaLeishmania braziliensisLeishmaniasisLeishmaniasis, MucocutaneousLymphocyte ActivationRegression AnalysisConceptsCutaneous DTHLeishmania antigenBraziliensis infectionTegumentary leishmaniasisIFAT titersDisease formsVitro lymphocyte proliferative responseCutaneous DTH responseHuman tegumentary leishmaniasisL. braziliensis infectionLymphocyte proliferative responsesImmune response parametersHigher IFAT titersNew World leishmaniasisPanamensis infectionDTH responseMucocutaneous diseaseClinical presentationLesion durationCutaneous diseaseDisease presentationImmune mechanismsImmune responseProliferative responseTime of evolution