Viability and Burden of Leishmania in Extralesional Sites during Human Dermal Leishmaniasis
Romero I, Téllez J, Suárez Y, Cardona M, Figueroa R, Zelazny A, Saravia N. Viability and Burden of Leishmania in Extralesional Sites during Human Dermal Leishmaniasis. PLOS Neglected Tropical Diseases 2010, 4: e819. PMID: 20856851, PMCID: PMC2939031, DOI: 10.1371/journal.pntd.0000819.Peer-Reviewed Original ResearchConceptsLeishmaniasis patientsExtralesional sitesNormal skinTonsil swabsViable parasitesDissemination of LeishmaniaMucocutaneous leishmaniasis patientsMonocyte samplesPositive samplesLuciferase activityParasite viabilitySkin aspiratesActive diseaseDermal leishmaniasisHuman leishmaniasisBlood monocytesEpidemiologic investigationsPatientsLeishmania DNAParasite burdenHuman infectionsIntracellular amastigotesLesionsSwabsEpidemiological significanceT-bet, GATA-3, and Foxp3 Expression and Th1/Th2 Cytokine Production in the Clinical Outcome of Human Infection with Leishmania (Viannia) Species
Díaz YR, Rojas R, Valderrama L, Saravia NG. T-bet, GATA-3, and Foxp3 Expression and Th1/Th2 Cytokine Production in the Clinical Outcome of Human Infection with Leishmania (Viannia) Species. The Journal Of Infectious Diseases 2010, 202: 406-415. PMID: 20583921, PMCID: PMC4850829, DOI: 10.1086/653829.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsCoculture TechniquesCytokinesFemaleForkhead Transcription FactorsGATA3 Transcription FactorGene ExpressionGene Expression ProfilingHumansLeishmaniaLeishmaniasisLeukocytes, MononuclearMaleMiddle AgedT-Box Domain ProteinsTh1 CellsTh2 CellsTreatment OutcomeYoung AdultConceptsGATA-3 expressionT cell differentiationTumor necrosis factor alphaT-bet expressionNecrosis factor alphaT-betHuman infectionsGATA-3Th2 responsesAsymptomatic infectionFactor alphaInterleukin-4Cutaneous leishmaniasisInterferon gammaTh1/Th2 cytokine productionTh1/Th2 cytokine responseHigher T-bet expressionTh1/Th2 responseActive recurrent diseaseRecurrent cutaneous leishmaniasisTh2 cytokine responsesExperimental cutaneous leishmaniasisProinflammatory cytokine interferon-gammaInterleukin-10 secretionTh2 cytokine production