2020
The NBDY Microprotein Regulates Cellular RNA Decapping
Na Z, Luo Y, Schofield JA, Smelyansky S, Khitun A, Muthukumar S, Valkov E, Simon MD, Slavoff SA. The NBDY Microprotein Regulates Cellular RNA Decapping. Biochemistry 2020, 59: 4131-4142. PMID: 33059440, PMCID: PMC7682656, DOI: 10.1021/acs.biochem.0c00672.Peer-Reviewed Original ResearchMeSH KeywordsHEK293 CellsHumansNonsense Mediated mRNA DecayOpen Reading FramesRNA CapsRNA StabilityRNA, MessengerConceptsP-bodiesNonsense-mediated decay factorsKO cellsSmall open reading framesCytoplasmic ribonucleoprotein granulesOpen reading frameSubstrate transcriptsCellular transcriptomeRibonucleoprotein granulesTarget transcriptsRNA stabilityKnockout cellsUTR lengthReading frameGlobal profilingProteogenomic identificationMacromolecular complexesHuman RNACellular RNACytoplasmic RNAGene stabilityAmino acidsCell growthMicroproteinsTranscripts
2018
P‑Bodies: Composition, Properties, and Functions
Luo Y, Na Z, Slavoff SA. P‑Bodies: Composition, Properties, and Functions. Biochemistry 2018, 57: 2424-2431. PMID: 29381060, PMCID: PMC6296482, DOI: 10.1021/acs.biochem.7b01162.Peer-Reviewed Original ResearchConceptsP-bodiesMRNA decayMRNA decay machineryLiquid-liquid phase separationP-body functionPost-transcriptional regulationDecay machineryProcessing bodiesTranslational repressionEukaryotic cellsCytoplasmic ribonucleoproteinCellular localizationRibonucleoproteinMolecular compositionRecent advancesRepressionMachineryProteinMRNARegulationFunctionCellsLocalizationDiscoveryComposition
2016
A human microprotein that interacts with the mRNA decapping complex
D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. A human microprotein that interacts with the mRNA decapping complex. Nature Chemical Biology 2016, 13: 174-180. PMID: 27918561, PMCID: PMC5247292, DOI: 10.1038/nchembio.2249.Peer-Reviewed Original Research
2012
Peptidomic discovery of short open reading frame–encoded peptides in human cells
Slavoff SA, Mitchell AJ, Schwaid AG, Cabili MN, Ma J, Levin JZ, Karger AD, Budnik BA, Rinn JL, Saghatelian A. Peptidomic discovery of short open reading frame–encoded peptides in human cells. Nature Chemical Biology 2012, 9: 59-64. PMID: 23160002, PMCID: PMC3625679, DOI: 10.1038/nchembio.1120.Peer-Reviewed Original Research