2020
Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease
Wadhwa A, Schaefer S, Gerrard J, Deeb W, Okun MS, Patel A. Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease. Tremor And Other Hyperkinetic Movements 2020, 10: 17. PMID: 32775031, PMCID: PMC7394224, DOI: 10.5334/tohm.62.Peer-Reviewed Original ResearchMeSH KeywordsDeep Brain StimulationEssential TremorHumansMaleMiddle AgedParkinson DiseaseSubthalamic NucleusConceptsDeep brain stimulationParkinson's diseaseEssential tremorHead trialsDBS targetsAction tremorSubthalamic nucleus (STN) DBSThalamus deep brain stimulationLimited evidenceDBS target selectionVentral intermediate nucleusBilateral STNPD patientsDBS treatmentEquivalent efficacyRest tremorMild improvementCurrent evidenceET patientsET tremorBrain stimulationComparative efficacyPatientsExpert consensusTremor reduction
2017
Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches
Schaefer SM, Rodriguez A, Louis ED. Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches. Expert Review Of Neurotherapeutics 2017, 18: 101-110. PMID: 29206482, DOI: 10.1080/14737175.2018.1413353.Peer-Reviewed Original ResearchConceptsEssential tremorGABA systemReceptor subtypesΓ-aminobutyric acid (GABA) neurotransmissionT-type calcium channelsHuman data pointUnderlying biochemical dysfunctionGABA-ergic neuronsRole of GABAInferior olivary nucleusPurkinje cell outputCertain GABANumerous medicationsClinical guidelinesPharmacotherapeutic approachesOlivary nucleusGABA receptorsPubMed searchCalcium channelsBiochemical dysfunctionNeurochemical systemsBrain circuitsMedicationsDegeneration modelGABA