Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches
Schaefer SM, Rodriguez A, Louis ED. Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches. Expert Review Of Neurotherapeutics 2017, 18: 101-110. PMID: 29206482, DOI: 10.1080/14737175.2018.1413353.Peer-Reviewed Original ResearchConceptsEssential tremorGABA systemReceptor subtypesΓ-aminobutyric acid (GABA) neurotransmissionT-type calcium channelsHuman data pointUnderlying biochemical dysfunctionGABA-ergic neuronsRole of GABAInferior olivary nucleusPurkinje cell outputCertain GABANumerous medicationsClinical guidelinesPharmacotherapeutic approachesOlivary nucleusGABA receptorsPubMed searchCalcium channelsBiochemical dysfunctionNeurochemical systemsBrain circuitsMedicationsDegeneration modelGABA