2014
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA. Cell 2014, 159: 1563-1577. PMID: 25525875, PMCID: PMC4272443, DOI: 10.1016/j.cell.2014.11.037.Peer-Reviewed Original ResearchConceptsMitochondrial outer membrane permeabilizationCell deathOuter membrane permeabilizationType I interferonDNA-dependent activationCaspase-dependent mannerI interferonCGAS/STING pathwayMitochondrial DNAApoptotic caspasesMembrane permeabilizationActive caspasesProapoptotic caspasesMitochondriaCaspasesSTING pathwayIFN responseAntiviral immunityCentral roleDual controlPathwayProinflammatory typeInductionCellsActivation
2007
Endoplasmic Reticulum Stress-induced Death of Mouse Embryonic Fibroblasts Requires the Intrinsic Pathway of Apoptosis*
Masud A, Mohapatra A, Lakhani SA, Ferrandino A, Hakem R, Flavell RA. Endoplasmic Reticulum Stress-induced Death of Mouse Embryonic Fibroblasts Requires the Intrinsic Pathway of Apoptosis*. Journal Of Biological Chemistry 2007, 282: 14132-14139. PMID: 17371867, DOI: 10.1074/jbc.m700077200.Peer-Reviewed Original Research
2006
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis
Lakhani SA, Masud A, Kuida K, Porter GA, Booth CJ, Mehal WZ, Inayat I, Flavell RA. Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis. Science 2006, 311: 847-851. PMID: 16469926, PMCID: PMC3738210, DOI: 10.1126/science.1115035.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisApoptosis Inducing FactorBcl-2-Associated X ProteinCaspase 3Caspase 7CaspasesCell NucleusCell ShapeCell SurvivalCells, CulturedCytochromes cDNA FragmentationFemaleFibroblastsHeartHeart Defects, CongenitalMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial MembranesPermeabilityT-LymphocytesConceptsApoptosis-inducing factorMitochondrial eventsDownstream effector caspasesDeath receptor-mediated apoptosisCytochrome c releaseCaspase-3Receptor-mediated apoptosisDefective nuclear translocationEarly apoptotic eventsMitochondrial membrane potentialEffector caspasesBax translocationC releaseCardiac developmentApoptotic eventsCaspase-7Upstream signalsNuclear translocationApoptosisMembrane potentialCritical mediatorKey mediatorTranslocationCaspasesEffectors